Zhenyu Sheng, PhD

Assistant Professional Specialist
University of Notre Dame

Education
BS, University of Science and Technology of China, 1998
PhD, University of Science and Technology of China, 2003
Postdoctoral Fellow, State University of New York, University of Albany 2003-2005

Address
W. M. Keck Center for Transgene Research
230 Raclin-Carmichael Hall
University of Notre Dame
Notre Dame, IN 46556

Contact
Phone: (574) 631-2318
Fax: (574) 631-4048
E-mail: zsheng@nd.edu

Research Interests
Dr. Sheng studies the electrophysiological consequences of the binding of agonists and antagonistics to the NMDA receptor, with special emphasis on the conantokin class of inhibitors of ion flow through the receptor ion channels.

Selected Recent Publications

Sheng Z, Prorok M, Brown BE, Castellino FJ. (2008).  N-methyl-D-aspartate receptor inhibition by an apolipoprotein E-derived peptide relies on low-density lipoprotein receptor-associated protein.  Neuropharm. 55:204-214.

Sheng Z, Dai Q, Prorok M, Castellino FJ. (2007).  Subtype-selective antagonism of N-methyl-D-aspartate receptor ion channels by synthetic conantokin peptides.  Neuropharm. 53:145-156.

Dai Q, Sheng Z, Geiger JH, Castellino FJ, Prorok M. (2007).  Helix-helix interactions between homo- and heterodimeric gamma-carboxyglutamate-containing conantokin peptides and their derivatives.  J Biol Chem. 282:12641-12649.

Pan Y, Sheng Z, Ye X, Ao Z, Chu G, Dai J, Yu S. (2005).  Photochemistry of quinoxaline derivatives and mechanism of the triplet state quenching by electron-poor alkenes. J Photochem Photobiol A: Chemistry 174:98-105.

Li G, Sheng Z, Huang Z, Niu L. (2005).  Kinetic mechanism of the channel opening of GluR4flip AMPA receptor.  Biochemistry 44:5835-5841.