| BIOLOGICAL
SCIENCES |
|
Project
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Inventor
|
Patent Status
|
Plasmodium Proteins Useful For Preparing Vaccine Compositions
"Dr. Adams invented a vaccine composition comprising an erythrocyte
binding protein of a Plasmodium parasite (MAEBL), or fragment thereof
for vaccinating against malaria infections." |
John H.
Adams
|
US Patent # 6,120,770
|
Nucleic Acid Sequences Encoding A Dendroides Antifreeze Protein
"A broad 'range of insects have been reported to produce thermal-hysteresis
proteins (THPs)' which 'are believed to play an important role in many
plant and animal species' ability to survive exposure to subzero temperatures.'
Dr. Duman’s second invention 'describes the nucleic acid sequences
encoding antifreeze proteins" that can be used to prevent or limit
ice growth or recrystalization of frozen goods, and provide protection
from damage that normally would result from freezing biological materials." |
John G.
Duman
|
US Patent # 5,627,051
|
Transgenic Plants Having A Nucleic Acid Sequence Encoding A Dendroides Antifreeze Protein
"Dr. Duman has produced a stably transformed plant cell, seed or
plant from the in vitro introduction of DNA sequences encoding a Dendroides
antifreeze protein into a plant cell. These antifreeze proteins are believed
to play an important role in many plant and animal species' ability to
survive exposure to subzero temperatures. Thus, his invention can be
used to prevent or limit ice growth or recrystalization of frozen goods,
and provide protection from damage that normally would result from freezing
biological materials." |
John G.
Duman
|
US Patent # 5,633,451
|
PiggyBac transposon-based genetic transformation system for insects
"The present invention identifies the specific sequences in a mobile
genetic element, the transposon piggyBac and the sequence configurations
outside of piggyBac, that are minimally required for full functionality
of the sequence as a transposon. The efficiency of inserting DNA molecules
into cells is enhanced using the methods and compositions of the present
invention." |
Malcolm
J. Fraser, Jr.
|
US Patent # 6,551,825
|
DNA Vector and Method for Transforming Eukaryotes (piggyBac)
"Dr. Fraser’s invention derives recombinant DNA vectors from
piggyBac and tagalong transposons. In general, his invention provides
new vectors and broad-spectrum methods for the introduction of foreign
genes into eukaryotic cells." |
Malcolm
J. Fraser, Jr.
|
US Patent # 6,218,185
|
Interplasmid Transposition Demonstrates piggyBac Mobility in Vertebrate Species
"The piggyBac transposon is an extremely versatile helper-dependent vector for gene transfer and germ line transformation in a wide range of eukaryotic species. Analyses of genome sequencing databases have identified piggyBac homologues among several sequenced animal genomes, including the human genome. We have demonstrated that this insect transposon is capable of transposition in primate cells and embryos of the zebrafish, Danio rerio. piggyBac mobility was demonstrated using an interplasmid transposition assay that has consistently predicted the germ line transformation capabilities of this mobile element in several other species. Both transfected COS-7 primate cells and injected zebrafish embryos support the helper-dependent movement of tagged piggyBac element between plasmids in the characteristic cut-and-paste, TTAA target-site specific manner." |
Malcolm
J. Fraser, Jr.
|
Patent Application # PCT/US2007/005072
|
| CHEMISTRY/BIOCHEMISTRY |
|
Project
|
Inventor
|
Patent Status
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Protein Folding Tool
"The study of protein assembly in the cell is crucial to the advancement
of medicine. In the past decade, researchers have discovered that many
human diseases are caused by improper protein folding. In many cases
(for example cystic fibrosis and many forms of cancer), folding fails
during the synthesis of a specific protein. A novel research tool to
aid the study of protein folding has been developed at Notre Dame. This
new technique provides a way to study protein folding in the native environment,
the cell. Ultimately, these studies can lead to a better understanding
of how proteins fold, which could allow researchers to determine more
effective treatments for diseases caused by the failure of protein folding." |
Clark et
al.
|
US Patent Application
# 11/211,723
|
Near Infrared Fluorescent Dye
"Recent technical advances in fluorescence microscopy have a major impact on cell imaging technique resulting in better quality images obtained using single molecule methods. However, the technical advances have to be complemented by employing bright and highly stable luminescent probes that do not undergo photobleaching or photolinking in order for the full potential to be realized.
Researchers at the University of Notre Dame have developed a family of dye that has an emission wavelength of 650-900 nm that are a superior substitute for Cy-5 dye. The dyes have been synthesized, tested on various cells and animal systems, and found to be effective using an epifluorescence microscope and a standard Cy-5 filter set. It has been also been shown that the dye is highly stable permitting time course fluorescence imaging experiments to be carried without losing much signal.
" |
Bradley Smith
|
US Patent Application
# 60/936,493
|
Carbon Nanotube Scaffolds for Harvesting Photons
" The photocatalytic activity of nanostructured semiconductor films has been widely explored in designing solar cells, solar hydrogen production and environmental remediation. Single wall carbon nanotube (SWCNT) architecture when employed as conducting scaffold in semiconductor nanostructure based photoelectrochemical solar cell can boosts the photoconversion efficiency by a factor of two.
Researchers at the University of Notre Dame have developed methods to enhance the incident photon to current conversion efficiency (IPCE) from 7.36% (at 350 nm) to 16%. This nearly doubling of the photoconversion efficiency is an indication of the improved charge collection efficiency using SWCNT network. This technology can be used in the following application:
(1) Develop next generation solar cells based on semiconductor quantum dots and nanostructures
(2) Solar hydrogen production
(3) Microcapacitors and storage battaries
(4) Solar-Fuel cell hybrids
" |
Prashant Kamat
|
US Patent Application # 60/934,403
|
Process For 1.10-Phenanthroline Ligands
"The new method...will provide chiral phenanthroline ligands in
general for applications in asymmetric synthesis. Phenanthrolines and
their complexes also have other uses such as their roles as reagents
for cleavage of DNA, as models for metalloenzymes, and other applications." |
Paul Helquist
|
US Patent
# 6,730,788
|
Bicyclic Beta-Lactams And Process Therefor
"Dr. Miller patented a methodology for the preparation of important
antibiotic and enzyme inhibitors. The process allows for the preparation
of a bicyclic .beta.-lactams which forms part of the molecular structure
of the .beta.-lactam antibiotics, notably the penicillins and the cephalosporins,
as well as numerous other antibiotics and .beta.-lactamase inhibitors." |
Marvin
J. Miller
|
US Patent # 5,750,681
|
Process For Bicyclic .Beta.-Lactams Diazo-.Beta.-Keto-Butyrate-Intermediates
For Bicyclic .Beta.-Lactams
"This invention relates to bicyclic .beta.-lactam compounds. In
particular it relates to a process for preparing fused bicyclic .beta.-lactam
1-carbapenams and 1-carbacephems and to intermediates useful therein." |
Marvin
J. Miller
|
US Patent # 5,106,968
|
Molecular Probes that Detect Apoptotic Cells
"A novel family of synthetic molecular probes have been developed
to selectively bind to cell membranes rich in phosphatidylserine. These
compounds may be used as a biomarker to detect apoptosis or be employed
as high through-put screens for cancer drug development. The advantages
of this technology are that the probes are stable and the reporter groups
have fluorophores suitable for fluorescence microscopy and flow cytometry
commonly used in the market. This technology is ready to be commercialized
by interested parties." |
Bradley
D. Smith
|
US Patent # 10/656,237
|
Derivatives of Epothilone B and D
"Epothilone B is a polyketide natural product isolated from myxobacterium
Sorangium cellulosum. This compound has been shown to be a viable drug
candidate. A novel, chemically unique analogue of epothilone B has been
synthesized. Biological testing of the material has shown significant
activity against a number of tumor cell lines. The activity of this compound
suggests that analogues based on modification may lead to new leads in
cancer chemotherapy." |
Richard
E. Taylor
|
US Patent # 6,900,331
|
One-Step Solubilization, Alignment, and Electrophoretic Deposition of Carbon Nanotubes as Thin Films
"The solubilization, alignment, and deposition of Carbon Nanotubes (CNT) have proven to be quite challenging for scientists.
An innovative new technology developed by University of Notre Dame researchers will have a significant impact on this process as it enables one step solubilization of CNTs using an organic solvent, electrophoretic alignment of CNTs, and a novel method of casting CNT films on conducting electrode surfaces.
Carbon Nanotubes are the ideal building blocks for the next generation nanodevices, and can be used in different areas including i) development of portable fuel cells based on conventional consumables (methanol and air) for small electronic appliances (e.g., lap-tap computers, cellular phones) ii) minimizing the use of precious metals in fuel cells by developing high surface area electrode materials and nanostructured carbon electrode -membrane assemblies, and iii) to design microelectrodes and microcapacitors. The advantages of This Technology includes:
i) able to serve as catalytically active nanostructured carbon supports,
ii)more effective way of depositing carbon nanostructures than the commonly used ink-paint method, iii)
One-step solubilization of carbon nanotubes in an organic solvent and their alignment in a DC field is capable of producing microelectrodes for electronic and sensor applications
" |
Prashant Kamat
|
US Patent Application #
11/192,097
|
New Synthetic Approach for the Production of Chiral Organic Fragments
"Chemists from Notre Dame have developed a new method for the synthesis of functionally-rich chiral fragments that can be used towards the synthesis of many natural products including polyketides as well as chiral building blocks for drug modification and library design. The method is high yielding and stereoselective for the formation of iodo-diethers or iodo-diol mono ethers. Moreover, the demonstrated ability to trap the intermediate with a variety of nucleophiles offers additional opportunities for synthetic creativity for chemical diversity generation." |
Richard
E. Taylor
|
US Patent Pending
#
|
Method for Enantiomeric Excess Prediction in Rh(I) Hydrogenations
"Researchers at Notre Dame have developed a virtual screen that
allows the computational prediction of the preferred enantiomer in the
Rh(I) catalyzed hydrogenations reaction in a matter of hours. Using Q2MM
modeling, Monte Carlo simulation, and Boltzman averaging one can predict
the favorable stereoisomer that will result in a reaction thus saving
time and effort." |
Olaf G.
Wiest
|
Patent Application #
PCT/US2007/064824
|
| ENGINEERING |
|
Project
|
Inventor
|
Patent Status
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Plug-in Sensor Board
"This invention is an ultra-low cost, multi-modality sensor board
for wireless radios, specifically the 802.15 Zigbee standard. This product
will deliver the first customizable distributed sensing technology to
satisfy customers’ specific application-oriented requirements at
a very low cost and with minimal complexity. It provides the first “plug-in” sensor
board solution to the emerging Zigbee Telos market and outperforms competing
products in the existing markets by providing customization service,
more sensor modalities with higher sensitivities and at a lower price.
The sensor boards can be directly “plugged in” radio boards
(Zigbee Telos or Mica) to compose sensing nodes with capabilities of
sensing, computation, programming and communication to form large-scale
wireless sensor networks that may consist of tens to thousands of such
nodes. Sensors on the nodes can be easily customized according to customers’ requirements
on sensor modalities, sensitivities, prices, etc. These nodes can also
be used as building blocks for bigger systems with more functionality." |
Peter H.
Bauer
|
US
Patent Pending Application #
|
Mobile Sensor Networks
"A new navigation and guidance principle for ultra-low complexity
mobile sensor networks promises superior robustness, fault tolerance,
scalability and cost/performance ratio. The navigation principle allows
one to allocate a large number of mobile nodes through basic neighborhood
interaction principles for sensing and tracking tasks. Locally detected
signals are amplified through the use of radio beacons that attract a
nearby node. Collision avoidance beacons are used to distribute nodes
in areas of interest (regions of attraction) with certain (variable)
densities. This “heterogeneous swarm” principle facilitates
the construction of large scale mobile sensor networks that can cover
large geographical areas." |
Peter H.
Bauer and Matthias J. Scheutz
|
US
Patent Application #
60/739,503
|
System for Inter-Chip Communication
"Quilt Packaging is a new method of interconnecting Integrated Circuits
(ICs) that improves communications among ICs. Conventional packaging
includes either a single IC per package, or several ICs interconnected
on a multilevel substrate. QP employs conducting nodules that protrude
beyond the edges of ICs allowing two or more ICs to be electrically connected
through the nodules, effecting high-speed, low-power signal paths. ICs
are pushed together so that the nodules touch each other (and are soldered
or welded together) so that signal paths are reduced to distances on
the order of the chip size at most, and as short as a few microns at
the least. The resulting "quilt" of die looks very much electrically
like a single, larger, monolithic IC." A short presentation can
be seen at http://www.nd.edu/~gbernste/quiltpackaging/QP%20updated%20presentation.pdf |
Gary H.
Bernstein
|
US
Patent Application #
10/933,417
|
Purification of Gas with Liquid Ionic Compounds
"The exciting part of this new technology is that the solvent, the
ionic liquid, will not dissolve in the gas stream. This is what would
enable the use of a supported liquid membrane. These problems [with using
normal liquids and conventional absorbers] are totally eliminated by
the use of an ionic liquid." |
Joan Brennecke
/ Edward J. Maginn
|
US
Patent #
6,579,343
|
Ionic Liquids
"The thermal stability of these compounds is significantly greater
than the state-of-the-art thermal fluids and lubricants. Applications
include use as a lubricant for high and/or low pressure service; as a
gas or liquid separation media; as an electrolyte; as a thermal fluid;
as a solvent for chemical reactions." |
Joan Brennecke
/ Mark J. Muldoon / Edward J. Maginn
|
US
Provisional Patent Applications #
60/620,420 and
60/620,421
|
Microfluidic Device for Detecting Hardening of Particles in Suspension
"Sepsis is a condition that occurs when toxin producing bacteria
invade the blood stream. Septic shock, the end stage of sepsis, is responsible
for more deaths in the US each year (~215,000) than Lung Cancer, Breast
Cancer or Acute Myocardial Infraction. The earlier a clinician is able
to detect the onset of sepsis, the more successful his or her efforts
can be in saving the patient. Researchers at the University of Notre
Dame have developed a novel microfluidic device that is able to detect
the loss of flexibility of Red Blood Cells (RBCs). The loss of RBC flexibility
is believed to occur fairly early in the onset of Sepsis and the test
itself takes less than five minutes to produce results." |
Hsueh-Chia
Chang
|
US Patent Pending
# 60/777,371
|
Micro-device to detect presence and Proliferation of Bacteria at Low Bio-particle
Concentrations
"The ability to quickly detect the presence of bacteria and estimate
their count in samples of interest is a highly desirable goal for many
clinical, environmental, and food-safety applications. This technology
allows one to detect the presence of very low concentrations of bacteria
(~100 CFU/ml of E. coli) within ~3 hours compared to a day or two using
the conventional method." |
Hsueh-Chia
Chang
|
US Patent Pending
# 60/784,671 60/777,371
|
Information Harvesting on Wireless Networks
"This technology enables a wireless transceiver to gather information
about its surroundings without using an actual sensor. For example, it
can detect the movement of a wireless device (e.g., cell phone, wireless-enabled
laptop, sensor network node), and movement in the vicinity of a wireless
terminal or changes in its environment. This permits the use of standard
wireless devices for surveillance, intrusion detection, theft prevention,
velocity estimation, etc. without any additional hardware. This invention
takes a fresh look at a wireless phenomenon called "fading" and
creatively exploits standard capabilities of wireless receivers." |
Haenggi
et al.
|
US Patent Application
# 60/645,015
|
Oxidation Smoothing of AlGaAs Heterostructures
"This process is applicable for a wide range of optical waveguides
used in conventional semiconductor lasers and other photonic devices.
The inventors have developed a means for the practical elimination of
lithography and etch-induced sidewall roughness arising during the fabrication
of AlGaAs heterostructure devices incorporating vertically etched features.
A post-etching process for achieving a 10-100 fold reduction in sidewall
roughness of etched AlGaAs ridge geometry structures has been demonstrated.
Simulations predict that with the level of reduced sidewall roughness,
the waveguide optical scattering loss can in turn be reduced by 2-3 orders
of magnitude (to as low as 0.01-0.1 dB/cm)." |
Hall et
al.
|
US Provisional Patent
Application # 60/727,847
|
New Approaches to Radiation Therapy
"A key disadvantage to currently available radiation therapy technology
is prolonged treatment time. The “step-and-shoot” technique
of Intensity Modulated Radiation Therapy (IMRT) has advantages of precise
delivery, easy verification, and general availability. This innovative
new technology can significantly reduce IMRT treatment time with the
use of a novel algorithmic solution to the Static Leaf Sequencing (SLS)
problem in IMRT planning. This technology is ready to be customized for
a development partner." |
Luan et
al.
|
US Patent Application
# 11/085,510 and 11/085,529
|
Rogue Detection
"This technology will allow one to automatically detect the presence
of unauthorized wireless network devices (rogue devices) through the
analysis of network traffic characteristics. This is an important problem
as such devices pose a significant threat to private computer networks.
In addition, detection of such devices without the deployment of an expensive
antenna sensor network is very difficult and current technologies do
not provide effective solutions." |
Chad D.
Mano / Aaron Striegel
|
US Provisional Patent
Application # 60/752,945
|
Plasma Fairing for Landing Gear Noise Reduction
"This technology presents a method to reduce aircraft noise production during landing and takeoff approaches. Plasma actuators mounted on the landing gear will streamline the gear, control air flow separation, and reduce noise production. Plasma actuators mounted on the surface of landing gear create a “plasma fairing” that actively streamlines the gear. The plasma actuators consist of surface mounted electrodes to transport high momentum fluid toward the surface, giving rise to a local wall jet effect and reducing flow separation. Advantages of this Technology include (i) Significant gear noise reduction (ii) Eliminates gear access problems associated with mechanical fairings (iii) Avoids the high costs associated with active blowing or suction strategies (iv) Offers a wide variety of actuation through variable electrode arrangement (v) Very robust and easily retrofitted for current aircraft
." |
Flint O. Thomas
|
US Patent
Application # 11/686,153
|
Glass Catalyst for Diesel Particulate Filters
"Soot produced from the combustion of diesel engines is oxidized at high temperatures in filters utilizing precious metals. While not only being expensive, these high temperatures rob an engine of performance. In addition, exhaust standards are becoming more stringent requiring more efficient filters.
Researchers at the University of Notre Dame have discovered a new catalyst technology which is capable of promoting soot oxidation at lower temperatures without the cost or complication of current systems. A catalyst consisting of alkali ions, particularly potassium (K), can be used to facilitate the removal of particulate carbon and hydrocarbon material from engine exhaust. Key to this technology’s success is the way in which the alkali ions are bound in a lattice, either glass or crystalline. The catalyst’s specific structure releases potassium ions to control the oxidation reaction. This passive approach achieves the thermal stability and durability required in diesel filter while improving particulate removal performance. This innovation allows for alternative construction of diesel particulate filter utilizing cheaper and more effective oxidizing agents. Combustion temperatures required for oxidation of exhaust particulates can be lowered and therefore reduce the stress and wear on engine equipment." |
Paul McGinn
|
US Patent
Application # 12/021,108
|
Bit Interleaved Coded Modulation with Single Feedback
"Bit Interleaved Coded Modulation (BICM), while a simple and practical technique to achieve high data rates, contains sub-optimalities. These sub-optimalities result in significant capacity loss over communication channels. Researchers at the University of Notre Dame have developed a new BICM scheme with a single feedback for the AWGN channel - the standard model for satellite and wireline terrestrial communication. BICM with Single Feedback has been proven to increase achievable rates on the AWGN channel without the complexity or transmission delay in multiple decision feedback systems.
The use of Single Feedback has been shown to completely eliminate the BICM imposed capacity loss in 8-PSK and 16-QAM constellations. In addition, this feedback scheme has demonstrated significant improvement in the capacity of 16-PSK and 64-QAM constellations. This enables the designer to profitably use a denser constellation while achieving lower interference in bit processing. Single Feedback uses a single iteration to update the a-posteriori probabilities of each bit between the demodulator and the decoder thereby improving error performance. Normal binary error control codes can be used in addition to this feedback function. Further feedback is shown to be unnecessary as it does not help increase the achievable rate in any way. The advantages of this technology include (i)Lower power requirement for transmission (ii) Increased system throughput (i.e. reduced latency) (iii)Higher data fidelity without complex decoding/demodulation systems (iv) Easily integrated into existing communication systems
" |
Oliver Collins
|
US Provisional Patent
Application # 61/010,251
|
Device for identifying molecular docking
"Significant attention has been devoted to the phenomenon of molecular docking, which is seeing growing employment within a diverse range of applications. The capacity for DNA to bind to complementary DNA, or for a protein to bind to its specific ligand allows very specific molecular identification. Therefore, the ability to accurately and rapidly detect molecular docking is of interest, particularly within the diagnostics industry.
One important example of DNA-DNA docking detection can be found in micro-array probing for genetic identification. Unfortunately, detection of such docking is usually a time-intensive process requiring considerable peripheral equipment and trained technicians. Researchers at the University of Notre Dame have recently developed a device and associated methodology for rapidly identifying the occurrence of DNA-DNA docking. This development relies on the principle that docked DNA will alter the electrical behavior of nanocolloids and their aggregation patterns. Consequently, the researchers were able to identify DNA-DNA docking by visually examining nanocolloid suspension patterns near specifically designed electrodes at different alternating-current frequencies. This system is extendable to allow for detection of other types of molecular docking, such as antibody-antigen docking. The advantages include (i) Small sample volumes employed (ii) Rapid analysis time, within 20 minutes (iii) Sensitive detection limit without peripheral equipment (iv) Can be applied to DNA-DNA, protein-ligand, analyte-antibody, and other systems
" |
Hsueh-Chia Chang
|
US Provisional Patent
Application # 60/978,544
|
Nanofiber Formation via Electrospinning in an AC Field
"Fiber formation through the process of electrospinning has the potential of revolutionizing a number of industries including fabrics and protective clothing. Zein, a corn protein and byproduct of the ethanol industry, can be produced through DC electrospinning but lacked the strength of synthetics. The DC electrospinning technique formed a mesh network of fibers which were too disorganized and weak to be useful with out cost prohibitive additives. Notre Dame has refined and studied the formation of nanofibers under an AC field which produces fiber morphologies very different from those produced under DC fields. The new AC electrospinning technique can produce fibers capable of self-assembly. Threads produced under this technique are fused together and aligned unlike in previous techniques. Threads like the one in this picture are actually interconnected. By varying AC field parameters thread diameter, number of fibers per thread, and bead formation can be controlled. These characteristics greatly enhance the thread strength and ease the fiber manufacturing process. The advantages of this technology include (i)ability to increase thread strength without additives (ii)ability to control fiber density for desired characteristic (iii) Fabric can be formed from renewable and cheap resources
" |
Hsueh-Chia Chang
|
US Provisional Patent
Application # 61/063,286
|
Power and Bandwidth Allocation in OFDM Multihop Wireless Network
"The study of information rate maximization in orthogonal frequency division multiplexing (OFDM) networks has led to the development of efficiency seeking algorithms. The problem of information flow in multihop networks will be critical to the next generation of wireless networks. Solutions proposed by researchers at the University of Notre Dame considered novel approaches to these problems using variable power and frequency band division to maximize information subject to flow conservation constraints, i.e. a bottleneck link.
Low-Complexity Solution is a simple algorithm which is applicable to all two-hop networks. It provides a network with optimum performance in high SNR regimes while providing significant benefit over a fixed scheduling algorithm at moderate SNR.
Greedy Solution is an opportunistic routing scheme that can be applied to any multihop network and return near optimum performance. Subcarriers are chosen and assigned based on the principle of de-bottlenecking the communication path. In any given multihop path the link with the lowest data rate is assigned a division of the frequency band which maximizes that links communication rate. The path is then reexamined until all links are assigned a subcarrier. While the generalities involved in this algorithm are a tradeoff with the optimality provided by the simple solution, the greedy solution does provide a 5 dB benefit over the fix scheduling routing method. Advantages of this technology include (i) Maximization of communication rate through division of frequency band (ii) Efficient use of power, Power is used where power is needed
(iii) Optimum performance of wireless network at high SNR (iv) Near optimum performance at all other SNR
" |
Nicholas J. Laneman
|
US Provisional Patent
Application # 61/069,920
|
Grid Heating - Distributed Computing and Energy Conservation
"Soon the electric bill for IT systems will eclipse $7 billion. While the computational target varies widely some of this money will be spent on one end byproduct: waste heat. A Grid Heating system is capable of utilizing this heat and promoting responsible energy conservation.
Grid Heating leverages distributed computing concepts to relocate and network various processing units to heat sinks where the waste heat is needed. The heat sinks vary from industrial processes to large facilities. Grid heating technology maps the compute load to the thermal requirement, while also considering the entire compute environment with principle focus on operating temperatures, humidity, air particulate, and noise production. Primary waste heat transfer can occur through air or liquid media depending on the target heat sink.
For high performance applications, server numbers and locations are matched with each heat sink such that the processors run at high utilizations 24/7. For bursty or high throughput applications, processors can be dynamically tasked based on the local temperature setting and the location’s measured temperature. Jobs can be migrated around the Grid Heating network to meet the various heat demands. For facility applications seasonal variations are evaluated to provide the maximum energy benefit and equipment utilization.
This innovation makes economic and environmental sense. HPC and Data Centers save money in reduced capital and operating expenditures to cool IT equipment. Industrial and facility heating costs are lowered as the IT waste heat is directly utilized. Installing a 1 MW Grid Heating HPC could save an organization over $600,000 a year. Additionally, environmental conservation is advanced as waste heat from server banks is redirected to supplement and or replace traditional heating methods.
" |
Paul Brenner
|
US Provisional Patent
Application # 61/065,894
|
Electrochemical Synthesis Of Quasi-Periodic Quantum Dot And Nanostructure Arrays
"Dr. Miller invented a method of fabricating nanostructures. Nanostructures
have wide applications in electronics, optics, magnetics and superconductivity.
By introducing this new and useful method of producing quasi-periodic
quantum dot and nanostructure arrays, Dr. Miller avoids the significant
costs and damage generated by more traditional method." |
Albert E.
Miller
|
US Patent # 5,747,180
|
Environmentally Acceptable Inhibitor Formulations for Metal Surfaces
"Dr. Miller invented a composition for inhibiting the corrosion
of metal surfaces using permanganate and a very low concentration of
chromium (VI). His invention protects carbon steel and metal alloys from
corrosion in aggressive environments, especially environments containing
chloride ions." |
Albert
E. Miller
|
US
Patent # 6,183,547 |
SorbaShock Flooring
"Unlike hard flooring such as ceraimic, wood, and composites, SorbaShock
is designed to reduce forces on the body during impact, thereby potentially
mitigating the incidence of injuries in private home, nursing homes,
and hospitals. Technology is based on a re-design of US Patent #5,542,221 “Dual
Stiffness Flooring.” " |
Timothy
C. Ovaert
|
US
Patent Pending #
|
Textured Surfaces for Orthopedic Implants, Bone & Tissue Scaffolding,
and Doped Scaffold Material
"An innovative scaffold material and associated manufacturing process
that duplicates the microstructure of real tissue, and an innovative
way of entraining more lubricant into synovial joints and thereby reducing
wear." |
Steven
R. Schmid
|
US
Patent Pending #
|
Wavy Cylinder to Reduce Drag and Suppress Vortex-induced-vibration
"By suppressing vortex-induced vibration and reducing drag, wavy
cylinders of some predetermined fixed wavelength and steepness can greatly
improve material performance. This invention effects the unabated vortex-induced-vibrations
that lead to the premature failure of equipment." |
Albin Szewczyk
|
US Patent # 6,619,887
|
Device For Treating Gases Using Microfabricated Matrix Of Catalyst
"Dr. Wolf invented a method for forming a supported catalytic matrix
through microfabrication. His invention has both industrial and academic
uses allowing for better studies relating the rate, yield, conversion
and selectivity of reaction to the size, composition, spacing and geometry
of the catalytic particles." |
Eduardo
E. Wolf
|
US Patent # 5,688,474
|
| PHYSICS |
|
Project
|
Inventor
|
Patent Status
|
Reducing Vortex Flux Density In Superconducting Materials
Acording to Dr. Barabasi, "we believe that our invention, aimed
at reducing the vortex density in a superconductor, has the potential
to revive the devices that were not possible due to vortex motion, and
to improve existing devices." |
Albert-Lazlo
E. Barabasi
|
US
Patent #
6,469,880
|
Hermetically Sealed Fiber-Optic Bundle Feedthrough
"This invention can be used to transmit multiple optical signals,
or optical images, between two environments separated by a sealing material
that can provide a high fluid or gas differential pressure and/or a high
differential temperature. The optical fibers are flexible and can be
arranged to collect and deliver light in a multitude of configurations
(in Dr. Tanner's application, 70,000 fibers are arranged in a 360-degree
annular ring to collect and transmit light from a central location)." |
Carol E.
Tanner
|
US Patent # 6,445,869
|
UNPATENTED TECHNOLOGIES
|
|
Project
|
Inventor
|
References
|
Ear Biometrics
"Research has shown that the ear is a promising candidate for biometric identification. Building on previous work, the inventors showed that they were able to achieve rank-one recognition rate of greater than 95% with a sample size of greater than 400 using automatic ear region segmentation and 3D ear shape matching. This system addresses issues caused by hair and earrings occlusion therefore, making it a powerful tool to be used for ear biometrics." |
Kevin
Bowyer
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Yan P and Bowyer KW (2007). Biometic Recognition Using 3D Ear Shape. IEEE Trans. Pattern Anal. Machine Intell. 8:1-12.
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Lobund-Wistar Rat
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Researchers at the University Notre Dame have developed a rat strain that is valuable for investigators who are interested in using an animal model to study prostate cancer and its prevention. Compared to other available animal model, this rat strain is the only known model that develops spontaneous prostate cancer spontaneously which begins as a hormone-dependent tumor and then progresses to hormone-refractory metastatic prostate adenocarcinoma. More importantly, the prostate cancer in this rat strain shares developmental characteristics with those describedfound in aging human patients with refractory prostate cancer. It has been shown that the prostate cancer in the Lobund-Wistar rat can be decisively prevented by feeding them a diet rich containing a soy protein isolate/isoflavone supplement. This rat can be used as a model system for studying cancer prevention and therapy in man." |
Morris Pollard
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Pollard M. The Lobund-Wistar rat model of prostate cancer. J Cell Biochem Suppl. 1992;16H:84-8. Review.
Pollard M, Suckow MA. Dietary prevention of hormone refractory prostate cancer in Lobund-Wistar rats: a review of studies in a relevant animal model. Comparative Medicine 56:461-467, 2006.
Pollard M, Suckow MA. Hormone-refractory prostate cancer in the Lobund-Wistar rat.
Exp Biol Med (Maywood). 2005 Sep;230(8):520-6. Review.
Pollard M, Luckert PH, Sporn MB. Prevention of primary prostate cancer in Lobund-Wistar Rats by N-(4-Hydrozyphenyl)retinamide. Cancer Research 51:3610-3611, 1991.
Pollard M, Wolter W. Prevention of Spontaneous Prostate-related cancer in Lobund-Wistar Rats by a Soy Protein isolate/isoflavone diet. The Prostate 45:101-105, 2000.
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PA-III Cell line
"Researchers at the University of Notre Dame have created a cloned PA-III cell line from a rat prostate tumor. The cell line was derived from a germfree Lobund-Wistar rat with spontaneous advanced hormone-refractory prostate cancer. The cell line can be used as a model system for investigations on tumor biology and therapy. ” " |
Morris Pollard
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Chang CF, Pollard M. In vitro propagation of prostate adenocarcinoma cells from rats. Invest. Urol. 14:331-334, 1977.
Koutsilieris M. PA-III rat prostate adenocarcinoma cells (review).
In Vivo. 1992 Mar-Apr;6(2):199-203. Review.
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