Multi-Scale Cardiovascular Bioengineering Laboratory

INTEGRATIVE FRAMEWORK

Activities conducted in the MSCBL are organized in three main research thrusts, which are integrated within a unique framework:

THRUST 1: CARDIOVASCULAR HEMODYNAMICS CHARACTERIZATION

The hemodynamic environment near the structures and organs of the cardiovascular system is complex and characterized by 3-dimensionality, unsteadiness, heterogeneity and a wide range of Reynolds numbers. In addition, cardiovascular structures are also characterized by complex motions and deformations (e.g., heart valve leaflets, ventricles) that make the flow characterization even more challenging. The MSCBL has adopted both experimental and computational approaches to describe the flow environment through different cardiovascular structures. The current focus is on the hemodynamic characterization of the native aortic valve under normal and diseased states.

THRUST 2: CARDIOVASCULAR MECHANOBIOLOGY

Cardiovascular structures interact closely with their hemodynamic environment. Those interactions are critical to understand the mechanisms by which cardiovascular tissue remodels and disease initiates and progresses. In the context of the aortic valve, the structural components of the valve undergo constant renewal in response to mechanical loading. Similarly, alterations in mechanical loading have been shown to affect the function of the valve cells. However, the characterization of those mechanobiological relationships is hampered by the requirements of maintaining the cells in their native extracellular matrix while controlling their mechanical environment. The MSCBL has developed unique and innovative tools and methodologies to study the effects of native hemodynamic forces on valvular physiology and disease.

THRUST 3: OUTREACH

As recognized by NSF, the support of the public is necessary for a national environment that fosters innovation. Therefore, there is a need to introduce science, technology, engineering and mathematics (STEM) to the general population and demonstrate their impact in advancing the nation. An even bigger challenge is achieving these objectives with the young population. This effort is critical to prepare the next generation of engineers and to bridge the gender gap in STEM disciplines. The MSCBL contributes to this effort via three outreach initiatives.