Summary of the characteristics of the 43 investigated organisms:

The table contains for each organism,

1. number of substrate (N)

2. number of links (L)

3. number of individual reactions or temporary substrate-enzyme complexes (R)

4. number of enzymes (E)

5. exponent gin and gout

6. diameter of the metabolic network (D).

In the last two columns we list the ten substrates with the largest number of incoming (IN) and outgoing (OUT) links. The letters correspond to: a=H2O, b=ADP, c=orthophosphate, d=ATP, e=L-glutamate, f=NADP+, g=pyrophosphate, h=NAD+, i=NADPH, j=NADH, k=CO2, l=NH4+, m=CoA, n=AMP, o=pyruvate, p=L-glutamine, q=2-oxoglutarate, r='alpha'-D-glucose 1-phosphate, s=phospho`enol`pyruvate, t=acetyl-CoA, u=H+, v=uridine, w=cytidine, x=UMP, y=CMP, z=glycerol, a =D-fructose 6-phosphate. The color code of the fields denotes the different domains of life such a yellow = Archae green = Bacterium sky blue =Eukaryote.

 Models

ORFs

Kb

Organism Name / Links

N

L (IN)

L (OUT)

R

E

g (IN)

g (OUT)

D

Hub (IN)

Hub (OUT)

1

AP

1,631

1,670

Aeropyrum pernix

204

588

575

178

135

2.2

2.2

3.2

bacdelgfij

adbcegipfh

2

AG

2,491

2,178

Archaeoglobus fulgidus

496

1527

1484

486

299

2.2

2.2

3.5

abcdghefjk

adbijchemf

3

TH

1,866

1,751

Methanobacterium thermoautotrophicum

430

1374

1331

428

280

2.2

2.2

3.4

abcdgefkhi

adbicejfkh

4

MJ

1,811

1,740

Methanococcus jannaschii

424

1317

1272

415

264

2.2

2.3

3.5

abcdgekfnh

adbciejkhf

5

PF

1,932

1,581

Pyrococcus furiosus

316

901

867

283

191

2.0

2.3

3.4

abcdgeknfh

dabceipjhf

6

PH

1,825

1,739

Pyrococcus horikoshii

323

914

882

288

196

2.0

2.2

3.4

abdcgefknl

dabciepjhq

7

AA

1,744

1,591

Aquifex aeolicus

419

1278

1249

401

285

2.1

2.2

3.3

bcadgefhki

adbciejgfh

8

CQ

993

1,230

Chlamydia pneumoniae

194

401

391

134

84

2.2

2.3

3.4

bdcagfleri

dabciergfp

9

CT

867

1,057

Chlamydia trachomatis

215

479

462

158

94

2.2

2.4

3.5

bdacgfelrm

dbaciegrfp

10

CY

3,226

3,573

Synechocystis sp.

546

1782

1746

570

370

2.0

2.2

3.3

abcdegfhjk

adbicjehfg

11

PG

1,832

2,448

Porphyromonas gingivalis

424

1192

1156

374

254

2.2

2.2

3.3

abdcgefnkh

adbceipjhg

12

MB

4,108

4,094

Mycobacterium bovis

429

1247

1221

391

282

2.2

2.2

3.2

abdcgelfkm

adbceifhjq

13

ML

2,940

3,807

Mycobacterium leprae

422

1271

1244

402

282

2.2

2.2

3.2

abcdgefkml

adbceifjhq

14

MT

3,924

4,412

Mycobacterium tuberculosis

587

1862

1823

589

358

2.0

2.2

3.3

adbcghemjk

adbjhmceit

15

BS

4,093

4,215

Bacillus subtilis

785

2794

2741

916

516

2.2

2.1

3.3

abdcjhmegf

adhbjcimef

16

EF

2,966

3,209

Enterococcus faecalis

386

1244

1218

382

281

2.1

2.2

3.1

bdacgelfik

adbciefghj

17

CA

3,967

4,031

Clostridium acetobutylicum

494

1624

1578

511

344

2.1

2.2

3.3

abcdgefhlk

adbceijhfo

18

MG

532

580

Mycoplasma genitalium

209

535

525

196

85

2.4

2.2

3.5

bdcgzxuyos

adbcguvwos

19

MP

674

816

Mycoplasma pneumoniae

178

470

466

154

88

2.3

2.2

3.2

bcdgxoyasl

dabcgowvsr

20

PN

1,844

2,105

Streptococcus pneumoniae

416

1331

1298

412

288

2.1

2.2

3.2

abdcgelfno

adbceifghj

21

ST

1,697

1,851

Streptococcus pyogenes

403

1300

1277

404

280

2.1

2.2

3.1

abdcegfoln

adbceifohg

22

CL

1,908

1,938

Chlorobium tepidum

389

1097

1062

333

231

2.1

2.2

3.3

badcgenfki

dabceipgfq

23

RC

3,345

3,721

Rhodobacter capsulatus

670

2174

2122

711

427

2.1

2.2

3.4

abcdhgefjk

adbjhicmet

24

RP

854

1,112

Rickettsia prowazekii

214

510

504

155

100

2.3

2.3

3.4

bdacfegilm

dabicfemgt

25

NG

1,853

2,063

Neisseria gonorrhoeae

406

1298

1270

413

285

2.1

2.2

3.2

abdcgefkjh

adbiechfjg

26

NM

1,838

2,169

Neisseria meningitidis

381

1212

1181

380

271

2.2

2.2

3.2

abdcegfkli

adbecifhjg

27

CJ

1,641

1,641

Campylobacter jejuni

380

1142

1115

359

254

2.1

2.3

3.2

abdcegfkih

adbeicfgjh

28

HP

1,547

1,668

Helicobacter pylori

375

1181

1144

375

246

2.0

2.3

3.3

abcdgefnhk

dabciejfhp

29

EC

4,285

4,639

Escherichia coli

778

2904

2859

968

570

2.2

2.1

3.2

abcdhjemlf

adhjbciefm

30

TY

4,688

4,464

Salmonella typhi

819

3008

2951

1007

577

2.2

2.2

3.2

abcdhjegfm

adhjbciefm

31

YP

4,230

4,934

Yersinia pestis

568

1754

1715

580

386

2.1

2.2

3.3

abdcgeklfh

adbceihjfl

32

AB

1,884

1,971

Actinobacillus actinomycetemcomitans

395

1202

1166

380

271

2.1

2.2

3.2

bacdgefikl

adbciefhgj

33

HI

1,846

1,830

Haemophilus influenzae

526

1773

1746

597

361

2.1

2.3

3.2

abcdegfjhm

adbchiefju

34

PA

5,626

6,246

Pseudomonas aeruginosa

734

2453

2398

799

490

2.1

2.2

3.3

abdchjkgef

adjhbimcef

35

TP

1,031

1,138

Treponema pallidum

207

562

555

175

124

2.2

2.3

3.1

bdcgaelnfh

dabcegiplf

36

BB

1,666

1,520

Borrelia burgdorferi

187

442

438

140

106

2.3

2.4

3.0

bdgcaleifn

dabcgifea l

37

TM

1,846

1,861

Thermotoga maritima

338

1004

976

302

223

2.1

2.2

3.2

badcegfikn

dabceifgqh

38

DR

3,103

3,284

Deinococcus radiodurans

815

2870

2811

965

557

2.2

2.1

3.3

acbdhjgekm

adhbjcimef

39

EN

4,472

4,286

Emericella nidulans

383

1095

1081

339

254

2.1

2.2

3.3

abdcegjhfl

adbcjheifq

40

SC

6,259

12,058

Saccharomyces cerevisiae

561

1934

1889

596

402

2.0

2.2

3.3

abdcehjgkm

adbhcjeifm

41

CE

16,639

100,096

Caenorhabditis elegans

462

1446

1418

450

295

2.1

2.2

3.3

abdcjhelgk

adbhcjiefm

42

OS

8,384

4,265

Oryza sativa

292

763

751

238

178

2.1

2.3

3.5

badcegljkn

adbcehjifn

43

AT

9,460

36,506

Arabidopsis thaliana

302

804

789

250

185

2.1

2.3

3.5

badcegjhlk

adbcehjign