In 2001, Fr. George Konstantopoulos (Protopresbyter of St. Andrew Greek Orthodox Church of South Bend, IN) worked closely with Maria Calash (Notre Dame student), and James Giannokopoulos (Notre Dame student), Fr. Jocic Dragisa (Priest of Sts. Peter and Paul Serbian Orthodox Church of South Bend, IN), Deacon Stefanos Alexopoulos (Notre Dame student), and Virgil Andronache (Notre Dame student) to establish the first organized Orthodox Campus Fellowship for Michiana (serving the Orthodox student communities of Saint Mary's College, the University of Notre Dame, and Indiana University - South Bend).

Since then, Fr. Konstantopoulos and Fr. Mile Subotic (current Priest of Sts. Peter and Paul Serbian Orthodox Church) have continued to provide spiritual guidance for all the Eastern Orthodox students as well as opportunities for philanthropic activities, prayer services in various locations, and transportation to the canonically established Eastern Orthodox churches in Michiana. These Eastern Orthodox churches are members of the Standing Conference of Orthodox Churches of America.