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My
research focuses on the evolution, systematics, population genetics, and
genomics of two of the world's most important malaria vectors, Anopheles
gambiae and Anopheles funestus. This work seeks to uncover
the molecular basis for behavioral and physiological differences between
these malaria vectors, thus providing important information for vector-based
malaria control strategies. We are part of the renowned Center
for Tropical Disease Research and Training at the University
of Notre Dame and collaborate with many other research institutions
in Europe, Africa, and the United States.
Currently my laboratory focuses on five major areas of interest:
1.)
Population Genetics and Phylogeography of Anopeheles funestus.
2.) The
role of the Y chromosome of Anopheles gambiae in molecular systematics.
3.) Comparative genomics of Anopheles funestus and Anopheles
gambiae.
4.) Genetic basis for differences in incipient species of Anopheles
gambiae.
5.) Mechanisms for driving genome rearrangement in Anopheline vectors
of malaria: transposable elements.
My laboratory currently consists of two technical staff (Olga Grushko,
Marcia Kern), two postdoctoral fellows (Dr. Igor Sharakhov, Dr. Jaroslaw
Krzywinski), three graduate students (Aram Stump, Andy Michel, Mamadou
Coulibaly), and two undergraduate researchers (Michael Barnes, Mike Willard).
We also work closely with members of the Frank Collins laboratory at Notre
Dame.
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