Speaker: Dr. Ivet Bahar
From: Department of Computational Biology, University of Pittsburgh
Date / Time / Room: Thursday, April 20, 2006/ 4:00 PM / 120 DeBartolo Hall
Tea: 3:30 PM

Title: Protein Dynamics and Allostery Explored by Network Models

Abstract: Elastic network models have proven in recent years to serve as useful tools for understanding the collective machinery of proteins and their complexes. Inspired by the success of such network models, we recently proposed a new approach based on a Markovian propagation of signals to model the process of allosteric communication in complex structures. Application to GroEL-GroES unravels several conserved residues playing a key role in the ATP-mediation of chaperonin cycle.