Hyde Lab: Manuela Lahne

Postdoctoral Research Fellow

2002	Humboldt University, Berlin	Diploma
2006	University College, London	Ph.D. Physiology
	Thesis Title: Damage-induced signaling mechanisms in the neonatal rat cochlea
2008-2009	Queen Mary, University of London	Postdoctoral Research Fellow
	Project: Signaling during zebrafish muscle development

Research Interests

Zebrafish sensory organs, such as the retina and lateral line organs, have the remarkable capacity to regenerate their sensory receptors following damage and death. The non-neuronal glial cells, i.e. the Mueller glia in the retina are induced to proliferate and to provide new photoreceptors. A regenerative response requires the damaged/dying photoreceptors to communicate their impaired integrity to the neighbouring cells, which in turn have to sense and integrate such signals. My research focuses on unraveling the initial inter- and intracellular signaling mechanisms that trigger Mueller glia in the zebrafish retina to undergo proliferation.

Manuela Lahne & Jonathan Gale (2008). Damage-Induced Activation of ERK1/2 in Cochlear Supporting Cells Is a Hair Cell Death-Promoting Signal That Depends on Extracellular ATP and Calcium. J Neurosci 28(19):4918-4928