B.S. Biochemistry, Indiana University – Bloomington, 2007

Research

Jeff's research interests are primarily in the area of enzyme structure and function. Using a variety of techniques including steady-state and transient kinetics, he hopes to better understand the mechanisms used by several different enzyme families. He worked on elucidating the mechanism of a flavin-dependent siderophore monooxygenase and is currently involved in understanding the novel heme-dependent chlorite dismutase. Both enzymes appear to be important for bacterial iron acquisition and present interesting questions in the area of bacterial iron metabolism.

Publications

Mayfield, J.A., Frederick, R.E., Streit, B.R., Wencewicz, T.A., DuBois, J.L. Comprehensive Sepctroscopic, Steady-State and Transient Kinetic Studies of a Representative Siderophore-Associated Flavin Monooxygenase J. Biol. Chem. 2010

Frederick, R. F.; Mayfield, J. A.; DuBois, J. L. "Iron trafficking as an antimicrobial target", Biometals 2009, 22, 583.