VULM    Zentiva

1987  Ph.D., Organic Chemistry, Slovak University of Technology, Bratislava, Slovak Republic

         Advisor: Prof. Augustin Martvon

Thesis title:  "Synthesis and Biological Study of The Condensed Heterocyclic Derivatives."

1979  M.S., Organic Chemistry, Slovak University of Technology, Bratislava, Slovak Republic

         Advisor: Prof. Jaroslav Kovac

         Thesis title: “The Reactions of 5-Azido-2-furancarbaldehyde.”

1986  Czechoslovak Ministry of Health, for outstanding research results

1979  1st Class Honor in Organic Chemistry, Bratislava, Slovak Republic

1978  International Student Competition in Chemistry, Vesprem, Hungary

1977  International Student Competition, section Organic Chemistry, Prague, Czech Republic

1976  Student Competition in Organic Chemistry, Bratislava, Slovak Republic

2004 – Present Ass. Prof. Specialist in the College of Science, Department of Chemistry

                      and Biochemistry, University of Notre Dame, Indiana, USA

with Prof. Shahriar Mobashery, Drug Research

To perform laboratory research based on both liquid-phase synthesis and solid-phase combinatorial chemistry focusing an attention on preparation of new biologically active molecules to elucidate screening/testing in various biological assays.

2001 - 2003     Postdoctoral Researcher, Institute for Drug Research and Department of Chemistry, Wayne State University, Detroit, Michigan, USA

with Prof. Shahriar Mobashery, Drug Research

Synthesized 145 amino glycoside drugs attached with peptides residue, developed new biologically active substances for irreversible inactivation of metalloenzymes, determined the role of these enzymes in development of cancer, studied the mechanisms of drug resistance and the development of chemical strategies to overcome them.

1997- 2000      JST Researcher, Japanese Science and Technology, ERATO Photochirogenesis Project, Osaka, Japan

with Prof. Yoshihisa Inoue, Photochirogenesis

Synthesized and elucidated new macro cyclic ligands involving the chemistry of metallocenes, crownethers, calixarenes, and ruthenium bipyridine derivatives designed to be used as optically pure starting materials for the syntheses of chiral compounds. Enhanced chirality by electron/energy transfer from photo excited chiral compounds to achiral targets in order to produce new chiral centers.

1997 - 1990     Postdoctoral Researcher, Department of Chemistry, The University of Oxford, United Kingdom

with Prof. Paul D. Beer, Supramolecular Chemistry

Synthesized novel macro cyclic host receptor molecules containing redox and photoactive molecules attached to the calix[n]arene skeleton, designed these systems to complex cationic, anionic or neutral inorganic, or organic guest species.

1988 - 1990     Head, Organic Department, Drug Research Institute, Modra, Slovak Republic

Designed and lead a research program addressing complex issues in drug research, provided guidance to junior staff in compliance with Good Laboratory Practice (GLP) and Good Manufactory Practice GMP), prepared new strategies and research reports.

1979 - 1988     Research Officer, Chemistry Department, Drug Research Institute, Modra, Slovak Republic

Designed and synthesized (multi-step) cardiovascular and gastrointestinal drugs; synthesized, isolated, purified, and characterized numerous organic compounds; worked on a large-scale synthesis (up to 100 kg) using broad technology platform in an industrial environment to continuously improve production processes in the pharmaceutical plant Slovakofarma Hlohovec (Zentiva).

1984 - 1987     Graduate Research Assistant, Organic Chemistry Department, Slovak University of Technology, Bratislava, Slovak Republic

Synthetic methodology for construction of isomerically annelated ring systems of purine and studies of thermally induced transformation of azido substituted theophylline derivatives resulting in new condensed heterocycles.

1974 - 1979     Research Assistant, Chemistry Department, Slovak University of Technology, Bratislava, Slovak Republic

Chemistry of furan, especially transformation of 5-azido-2-furancarbaldehyde into five-, six- or seven-member nitrogen-containing heterocycles.

1971 - 1973     Research Assistant, Organic Chemistry Department, Slovak University of Technology, Bratislava, Slovak Republic