Patents

The Latest Work Papers Patents References

1.       Hesek, D.; Hembury, G. A.; Taniguchi, S.; Inoue, Y.Photosubstitution of ligand of ruthenium complex with retention of configuration. Jpn. Kokai Tokkyo Koho, No: 2002193936 (14pp), 2002.

2.       Ishida, H.; Hesek, D.; Inoue, Y. Spectrophotometry and its combined cells having plural branches with different optical-path length. Jpn. Kokai Tokkyo Koho, JP3750011, 2005 (App.No:2001147195, 7 pp, 2001). certificate of patent

3.       Hesek, D.; Inoue, Y.; Ishida, H.Photochromic cationic metal complex materials based on p-p interaction and method for isomerization thereof. Jpn. Kokai Tokkyo Koho, No: 2001139585 (10 pp), 2001.

4.       Ishida, H.; Hesek, D.; Inoue, Y.Preparation of metal bipyridine complexes and amino acid-modified metal complexes. Jpn. Kokai Tokkyo Koho, No: 2001039995 (9pp), 2001.

5.       Hesek, D.; Inoue, Y.; Ishida, H.One-pot preparation of cationic metal complexes of tris(2,2'-bipyridine derivative) and their chiral complexes. Jpn. Kokai Tokkyo Koho, JP3750010, 2005 (App.No: 2001039994, 17 pp, 2001). certificate of patent

6.       Ishida, H.; Hesek, D.; Inoue, Y.; Everitt, S. R. L.Preparation of metal complex cations useful for asymmetric synthesis of metal complexes. Jpn. Kokai Tokkyo Koho, No: 2000264895, (19 pp), 2000.

7.       Szemes, F.; Hesek, D.; Rybar, A.; Tegza, M.; Simkova, M.; Bachraty, F. Method of preparing 1-(2,6-dimethylphenoxy)2-propylamine (mexiletine). Czech CS 275,513 C.A. 119: P 203.135w (1993).

8.       Gomory, J.; Hesek, D.; Tegza, M.; Smahovsky, V.; Kacina, R.; Kmetty, G. Method of production of 7-(2-hydroxyethyl)theophylline[etofylline] by alkylation of theophylline with haloethanols and bases. Czech CS 267,313 (15 July 1991). C.A. 116: P 59 097d (1992).

9.       Rybar, A.; Tegza, M.; Repas, M. C.; Szemes, F.; Frimm, R.; Hesek, D.; Guttmann, M.; Turcani, P.; Mahrla, Z. Two-step alkylation method for the preparation of 3-methyl-1-(5-oxohexyl)-7-n-propyl-3,7-dihydro-1H-purine-2,6-dione [propentofylline]. Czech CS 270,545 (25 Jun 1991). C.A. 117: P 90 053f (1992).

10.   Rybar, A.; Tegza, M.; Repas, M. C.; Szemes, F.; Frimm, R.; Hesek, D.; Guttmann, M. One-pot synthesis of 3-methyl-7-prophyl-3,7-dihydro-1H-purine-2,6-dione in protic solvents. Czech CS 271,988 (24 Sep 1991). C.A. 117: P 171 090t (1992).

11.   Rybar, A;. Repas, M.; Tegza, M.; Hesek, D.; Nevydal, J.; Frimm, R.; Szemes, F. Preparation of the vasodilator intermediate 7-(n-propyl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione via alkylation with propyl halides. Czech CS 263,595 (15 July 1988). C.A. 113: P 40721 (1990).

12.   Rybar, A.; Repas, M.; Tegza, M.; Hesek, D.; Frimm, R.; Szemes, F.; Greiplova, E. Preparation of 6-amino-5-bromo-1-methyl-1H-pyrimidine-2,4-dione as vasodilator propentofylline intermediate. Czech CS 267.786 (30 July 1989). C.A. 114: P 228941 (1990).

13.   Rybar, A.; Repas, M.; Tegza, M.; Szemes, F.; Frimm, R.; Hesek, D.; Greiplova, E. Method for the preparation of 6-amino-5-bromo-1-methyl-1H-pyrimidine-2,4-dione as an intermediate for the vasodilator propentofylline. Czech CS 267.380 (14 Dec 1990). C.A. 114: P 231 997 (1990).

14.   Rybar, A.; Tegza, M.; Repas, M.; Hesek, D.; Frimm, R.; Szemes, F.; Guttmann, M. Method of preparing 3-methyl-7-n-propyl-3,7-dihydro-1H-purine-2,6-dione. Czech CS 267.796 (02 July 1990). C.A. 114: P 185 144 (1990).

15.   Rybar, A.; Repas, M.; Hesek, D.; Frimm, R;. Tegza, M.; Szemes, F. A method for the preparation of 3-methyl-7-n-propyl-3,7-dihydro-1H-purine-2,6-dione as an intermediate for vasodilator propentofylline. Czech CS 267,379 (14 Dec 1990). C.A. 115: P 207 763 (1990).

16.   Rybar, A.; Repas, M.; Tegza, M.; Szemes, F.; Frimm, R.; Hesek, D.; Guttmann, M. N-methylation of 3-methyl-3,7-dihydro-1H-purine-2,6-dione by methyl chloride. Czech CS 267,100 (14 Dec 1990). C.A. 115: P 279 704 (1990).

17.   Rybar, A.; Repas, M.; Tegza, M.; Hesek, D.; Frimm, R.; Szemes, F.; Turcani, P.; Mahrla, Z. A method for the preparation of 3-methyl-1-(5-oxohexyl)-7-n-propyl-3,7-dihydro-1H-purine-2,6-dione as an intermediate for vasodilator propentofylline. Czech CS 266,291 (13 July 1990). C.A. 115: P 207 764 (1990).

18.   Rybar, A;. Repas, M.; Tegza, M.; Hesek, D.; Nevydal, J.; Frimm, R.; Szemes, F. Preparation of the vasodilator intermediate 7-(n-propyl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione via alkylation of purinedione salts with propyl halides. Czech CS 263,200 (15 July 1988). C.A. 113: P 40720 (1990).

19.   Hesek, D.; Tegza, M.; Rybar, A.; Szemes, F.; Jezek, L.; Simko, M. Preparation of 1-(2,6-dimethylphenoxy)-2-propanone as an anthiarrithmic drug intermediate. Czech CS 246,872 (15. Jan 1988). C.A. 111: P 96 827j (1989).

20.   Rybar, A.; Repas, M.; Szemes, F.; Nevydal, J.; Hesek, D. Process for preparation of 5,6-diamino-1-methyl-2,4(1H,3H)-pyrimidinedione as a pharmaceutical intermediate. Czech CS 261.447 (30 July 1989). C.A. 112: P 261.447 (1990).

21.   Hesek, D.; Szemes, F.; Tegza, M.; Rybar, A.; Losova, O.; Martvon, A.; Simkova, M. Purification of the anthiarrithmic 1-(2,6-dimethylphenoxy)-2-aminopropane hydrochloride [mexiletine HCl]. Czech CS 250,577 (15 July 1988). C.A. 110: P 94 677r (1989).

22.   Nevydal, J.; Manduch M.; Siska, K.; Frimm, R.; Gattnar, O.; Hesek, D.; Rybar, A. Preparation of 1-(2,6-dimethylphenoxy)-2-propanone as an intermediate for pharmaceutics. Czech CS 245,189 (15. Oct 1987). C.A. 109: P 128 579g (1988).

23.   Szemes, F.; Rybar, A.; Hesek, D.; Tegza, M.; Kosalk,o R. Preparation of 1-(2,6-dimethylphenoxy)-2-propylamine as an anthiarrithmic drug. Czech CS 239,418 (16 Apr 1987). C.A. 109: P 92 467c (1988).

24.   Szemes, F.; Tegza, M.; Hesek, D.; Rybar, A.; Zlatinsky, E. Preparation of 1-(2,6-dimethylphenoxy)-2-propanol as intermediate for pharmaceuticals. Czech CS 235,184 (15. Feb 1987). C.A. 108: P 5 683h (1988).

25.   Tegza, M.; Hesek, D.; Rybar, A.; Kosalko, R.; Martvon A. Preparation of 1-(2,6-dimethylphenoxy)-2-propylamine. Czech CS 230,305 (15. Oct 1986). C.A. 108: P 131 2873n (1986).

26.   Janda, L.; Voticky, Z.; Ryba,r A.; Hesek, D. Ethyl 5-(5-phenyl-2-furyl)tetrazole-1-acetates. Czech CS 232,343 (15 July 1986). C.A. 106: P 33 069q (1987).

27.   Hesek, D.; Tegza, M.; Rybar, A.; Szemes, F.; Kosalko, R.; Martvon, A. 1-(2,6-Dimethylphenoxy)-2-propanone. Czech. CS 223,436 (15 Mar 1986). C.A. 105: P 226 047u (1986).

28.   Hesek, D.; Tegza, M.; Ryba,r A.; Martvon, A.; Kosalko, R. 1-(2,6-Dimethyphenoxy)-2-propylazide. Czech. CS 216,896 (31 Okt 1984). C.A. 102: P 220 562z (1984).

 

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