The latest effort

Yamaguchi, Takao; Blazquez, Blas; Hesek, Dusan; Lee, Mijoon; Llarrull, Leticia I.; Boggess, Bill; Oliver, Allen G.; Fisher, Jed F. and Mobashery, Shahriar “Inhibitors for Bacterial Cell-Wall Recycling.”

Medicinal Chemistry Letters 2012, (In press)

Jeong Soon Park, Woo Cheol Lee, Kwon Joo Yeo, Kyoung-Seok Ryu, Malika Kumarasiri, Dusan Hesek, Mijoon Lee, Shahriar Mobashery, Jung Hyun Song, Seung Il Kim, Je Chu Lee, Chaejoon Cheong, Young Ho Jeon, and Hye-Yeon Kim. "Mechanism of Anchoring of OmpA protein to the Cell Wall Peptidoglycan of the Gram-Negative Bacterial Outer Membrane."

FASEB J. 2011, 26 (1), 219-228.

Cesar Carrasco-López, Alzoray Rojas-Altuve, Weilie Zhang, Dusan Hesek, Mijoon Lee, Sophie Barbe, Isabelle André, Pilar Ferrer, Noella Silva-Martin, German R. Castro, Martín Martínez-Ripoll, Shahriar Mobashery, and Juan A. Hermoso. "Crystal Structures of Bacterial Peptidoglycan Amidase AmpD and an Unprecedented Activation Mechanism."

J. Biol. Chem. 2011, 286, 31714-31722.

Oleg Borbulevych, Malika Kumarasiri, Brian Wilson, Leticia I. Llarrull, Mijoon Lee, Dusan Hesek, Qicun Shi, Jeffrey Peng, Brian M. Baker, and Shahriar Mobashery. "Lysine N-Decarboxylation Switch and Activation of the B-Lactam Sensor Domain of BlaR1 Protein of Methicillin-resistant Staphylococcus aureus."

J. Biol. Chem. 2011, 286, 31466-31472

B. Maestro, L. Novakova, D. Hesek, M. Lee, E. Leyva, S. Mobashery, J. M. Sanz, and P. Branny. "Recognition of peptidoglycan and beta-lactam antibiotics by the extracellular domain of the Ser/Thr protein kinase StkP from Streptococcus pneumoniae."

FEBS Lett., 2011, 585, 357-363. (774Kb)

M. Lee, D. Hesek, I. M. Shah, A. G. Oliver, J. Dworkin and S. Mobashery. "Synthetic Peptidoglycan Motifs for Germination of Bacterial Spores."

ChemBioChem, 2010, 11, 2525-2529. (760 Kb)

Takao Yamaguchi, Dusan Hesek, Mijoon Lee, Allen G. Oliver, and Shahriar Mobashery. “Sulfonylation-Induced N- to O-Acetyl Migration in 2-Acetamidoethanol Derivatives.”

J. Org. Chem., 2010, 75(10), 3515-3517 (760 Kb)

Dusan Hesek, Mijoon Lee, Bruce C. Noll, Jed F. Fisher, and Shahriar Mobashery. “Complications from Dual Roles of Sodium Hydride as a Base and as a Reducing Agent.”

J. Org. Chem., 2009, 2009, 74, 2567–2570 (650 Kb)

Chen, Y.; Zhang, W.; Shi, Q.; Hesek, D.; Lee, M.; Mobashery, S.; Shoichet, B. K.. "Crystal Structures of Penicillin-Binding Protein 6 from Escherichia coli."

J. Am. Chem. Soc. 2009, 131, (40), 14345-14354. (4.2 Mb) JACS Impact Factors

Lee, M.; Hesek, D.; Noll, B. C.; Mobashery, S. "Key Side Products Due to Reactivity of Dimethylmaleoyl (DMM) Moiety as Amine Protective Group."

Chemical Papers 2009, 63, (5), 592-597. (258 Kb)

Gooyit, M.; Lee, M.; Hesek, D.; Boggess, B.; Oliver, A. G.; Fridman, R.; Mobashery, S.; Chang, M. "Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl) ethyl)thiiranes as potent gelatinase and MT1-MMP inhibitors."

Chem. Biol. Drug Des. 2009, 74, (6), 535-546. (371 Kb)

Hesek, D.; Lee, M.; Zhang, W.; Noll, B. C.; Mobashery, S. "Total Synthesis of N-Acetylglucosamine-1,6-anhydro-N-acetyl muramylpentapeptide and Evaluation of Its Turnover by AmpD from *Citrobacter freundii*."

J. Am. Chem. Soc. 2009, 131, (14), 5187-5193. (1.3 Mb) JACS Impact Factors

Lee, M.; Zhang, W.; Hesek, D.; Noll, B. C.; Boggess, B.; Mobashery, S. "Bacterial AmpD at the Crossroads of Peptidoglycan Recycling and Manifestation of Antibiotic Resistance."

J. Am. Chem. Soc. 2009, 131, (25), 8742-8743 (793 Kb) JACS Impact Factors

Testero, S. A.; O'Daniel, P. I.; Shi, Q.; Lee, M.; Hesek, D.; Ishiwata, A.; Noll, B. C.; Mobashery, S. "Regiospecific Syntheses of 6alpha -(1R-Hydroxyoctyl)penicillanic Acid and 6beta -(1R-Hydroxyoctyl) penicillanic Acid as Mechanistic Probes of Class D beta -Lactamases."

Org. Lett. 2009, 11, (12), 2515-2518. (1.0 Mb)

Lee, M.; Celenza, G.; Boggess, B.; Blase, J.; Shi, Q.; Toth, M.; Bernardo, M. M.; Wolter, W. R.; Suckow, M.; Hesek, D.; Noll, B. C.; Fridman, R.; Mobashery, M.; Chang, M. "A Potent Gelatinase Inhibitor with Anti-Tumor-Invasive Activity and its Metabolic Disposition."

Chem. Biol. Drug Des. 2009, 73, 189-202. (425 Kb)

Forbes, C.; Shi, Q.; Fisher, J. F.; Lee, M.; Hesek, D.; Llarrull, L. I.; Toth, M.; Gossing, M.; Fridman, R.; Mobashery, S. "Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases."

Chem. Biol. Drug Des. 2009, 74, (6), 527-534. (336 Kb)

Dusan Hesek, Mijoon Lee, Takao Yamaguchi, Bruce C. Noll, and Shahriar Mobashery. “A Facile Preparation of a Highly Functionalized Tetrahydropyran by Catalytic Hydrogenation of an Oxazoline.”

J. Org. Chem. 2008, 73 (18) 7349-7352. (425 Kb)

Maxim Suvorov, Mijoon Lee, Dusan Hesek, Bill Boggess, and Shahriar Mobashery. *"Lytic Transglycosylase MltB of Escherichia coli* and Its Role in Recycling of Peptidoglycan Strands of Bacterial Cell Wall."**

J. Am. Chem. Soc. 2008, 130, 11878–11879 (PDF 356 Kb) JACS Impact Factors

Adriel Villegas-Estrada, Mijoon Lee, Dusan Hesek, Sergei B. Vakulenko, and Shahriar Mobashery. “Co-opting the Cell Wall in Fighting Methicillin-Resistant Staphylococcus aureus: Potent Inhibition of PBP 2a by Two Novel Anti-MRSA β-Lactam Antibiotics.”

J. Am. Chem. Soc. 2008, 130, 9212–9213 (PDF 87 Kb) JACS Impact Factors

Mijoon Lee, Dusan Hesek, Qicun Shi, Bruce C. Noll, Jed F. Fisher, Mayland Chang, Shahriar Mobashery. “Conformational Analyses of Thiirane-Based Gelatinase Inhibitors.”

Bioorganic & Medicinal Chemistry Letters, 2008, 18, 3064-3067. (PDF 472 Kb ) Elsevier

Lee, M.; Hesek, D.; Mobashery, S. "Synthetic Efforts in Preparations of Components of the Bacterial Cell Wall."

Chemical Glycobiology, ACS Symposium Series 990, Washington 2008, Chapter 3, pp 54-78.

Sangwoo Cho, Qian Wang, Chittoor P. Swaminathan, Dusan Hesek, Mijoon Lee, Geert-Jan Boons, Shahriar Mobashery, and Roy A. Mariuzza. “Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins.”

Proc. Natl. Acad. Sci. U.S.A. 2007 104, 8761-8766 (PDF 1.05 MB ) High-Impact Journals

Inmaculada Pérez-Dorado, Nuria E. Campillo, Begoña Monterroso, Dusan Hesek, Mijoon Lee, Juan A. Páez, Pedro García, Martín Martínez-Ripoll, José L. García, Shahriar Mobashery, Margarita Menéndez,and Juan A. Hermoso. "Elucidation ot the Molecular Recognition of Bacterial Cell by Modular Pneumococcal Phage Endolysin CPL."

J. Biol. Chem. 2007, 282 (34) 24990-24999. (PDF 1.04 MB ) Most-Requested ACS Journals

Fuda, C.; Suvorov, M.; Shi, Q.; Hesek, D.; Lee, M.; Mobashery, S. "Shared Functional Attributes between the mecA Gene Product of Staphylococcus sciuri and Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus Aureus."

Biochemistry 2007, 46, 8050-8057. (PDF 344 Kb) Most-Requested ACS Journals

Dale Kling, Dusan Hesek, Qicun Shi, and Shahriar Mobashery. "Design and Synthesis of a Structurally Constrained Aminoglycoside. "

J. Org. Chem. 2007, 72, 5450-5453. (PDF 144 Kb) Most-Requested ACS Journals

Choonkeun Kim, Adriel Villegas-Estrada, Dusan Hesek, and Shahriar Mobashery. *“Mechanistic Characterization of the Bifunctional Aminoglycoside-Modifying Enzyme AAC(3)-Ib/AAC(6¢)-Ib¢ from Pseudomonas aeruginos.”*

Biochemistry. 2007, 46, 5270-5282. (PDF 253 Kb) Most-Requested ACS Journals

Dusan Hesek, Bruce C. Noll, and Shahriar Mobashery. “A Side Reaction of Significance in Preparation of Peptide- or Peptidomimetic-Based Hydroxamate Enzyme Inhibitors.”

J. Org. Chem. 2006, 71, 2885-2887. (PDF 82 Kb ) Most-Requested ACS Journals

Choonkeun Kim, Dusan Hesek, Jaroslav Zajíček, Sergei B. Vakulenko, and Shahriar Mobashery. "Characterization of the Bifunctional Aminoglycoside-Modifying Enzyme ANT(3″) Ii/AAC(6′)-IId from Serratia marcescens."

Biochemistry. 2006, 45, 8368-8377. (PDF 262 Kb ) Most-Requested ACS Journals

Dusan Hesek, Marta Toth, Viktor Krchňák, Rafael Fridman, and Shahriar Mobashery. “Synthesis of an Inhibitor-Tethered Resin for Detection of Active Matrix Metalloproteinases Involved in Disease.”

J. Org. Chem. 2006, 71, 5848-5854. (PDF 262 Kb ) Most-Requested ACS Journals

Mikhail Rekharsky, Dusan Hesek, Mijoon Lee, Samy Meroueh, Yoshihisa Inoue, and Shahriar Mobashery. "Thermodynamics of Interactions of Vancomycin and Synthetic Surrogates of Bacterial Cell Wall".

J. Am. Chem. Soc. 2006, 128, 7736-7737. (PDF 80 Kb ) JACS Impact Factors

Samy O. Meroueh, Krisztina Z. Bencze, Dusan Hesek, Mijoon Lee, Jed F. Fisher, Timothy L. Stemmler, and Shahriar Mobashery. “Three-Dimensional Structure of the Bacterial Cell Wall Peptidoglycan.”

Proc. Natl. Acad. Sci. U.S.A. 2006, 103 (12), 4404–4409. (PDF 1.45 MB) High-Impact Journals

Fuda, C.; Hesek, D.; Lee, M.; Heilmayer, W.; Novak, R.; Vakulenko, S. B.; Mobashery, S. Mechanistic Basis for the Action of New Cephalosporin Antibiotics Effective Against Methicillin- and Vancomycin-Resistant Staphylococcus aureus.

J. Biol. Chem. 2006, 281 (15), 10035–10041, 2006). (PDF 1.45 Kb ) Bioscience impact

Dusan Hesek, Marta Toth, Samy O. Meroueh, Stephen Brown, Huiren Zhao, Wael Sakr, Rafael Fridman, and Shahriar Mobashery. Detection and Characterization of a Metalloproteinase Inhibitor-tethered Resin for the detection of a Active Matrix Metalloproteinases in Biological Samples.

Chemistry & Biology 2006, 13, 379–386. (PDF 309 Kb) ZuckerPreviews (PDF 120 Kb) Bioscience impact

Toth, M.; Osenkowski, P.; Hesek, D.; Brown, S.; Meroueh, S.; Sakr, W.; Mobashery, S.; Fridman, R. “Cleavage at the Stem Region Releases an Active Ectodomain of the Membrane Type 1-Matrix Metalloproteinase”

Biochem. J. 2005, 387, 497–506 (Published as Immediate Publication) (PDF 387 Kb) Bioscience impact

Cosimo Fuda, Dusan Hesek, Mijoon Lee, Ken-ichiro Morio, Thomas Nowak, and Shahriar Mobashery. “Activation for Catalysis of Penicillin-Binding Protein 2a (PBP2a) of Methicillin-Resistant Staphylococcus aureus by Bacterial Cell Wall.”

J. Am. Chem. Soc. 2005, 127, 2056-2057 (PDF 51 Kb) JACS Impact Factors

Mijoon Lee, Dusan Hesek, and Shahriar Mobashery. “A Practical Synthesis of Nitrocefin.”

J. Org. Chem.; (Note); 2005, 70(1), 367-369 (PDF 103 Kb) Most-Requested ACS Journals

Dusan Hesek, Mijoon Lee, Ken-ichiro Morio, and Shahriar Mobashery. “Synthesis of a Fragment of Bacterial Cell Wall.”

J. Org. Chem.; (Article); 2004, 69(6), 2137-2146 (PDF 249 Kb) Most-Requested ACS Journals

Dusan Hesek, Maxim Suvorov, Ken-ichiro Morio, Mijoon Lee, Stephen Brown, Sergei B. Vakulenko, and Shahriar Mobashery. “Synthetic Peptidoglycan Substrates for Penicillin-Binding Protein 5 (PBP5) of Gram-Negative Bacteria.”

J. Org. Chem.; (Article); 2004, 69(3); 778-784 (PDF 181 Kb) Most-Requested ACS Journals

Mijoon Lee, Dusan Hesek, Maxim Suvorov, Wenlin Lee, Sergei Vakulenko, and Shahriar Mobashery. “A Mechanism-Based Inhibitor Targeting the DD-Transpeptidase Activity of BacterialPenicillin-Binding Proteins.”

J. Am. Chem. Soc.; (Article); 2003, 125, 16322-16326 (PDF 118 Kb) 2004 JACS Impact Factors

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