Publications
1. Auburn S, Diakite M, Fry AE, Ghansah A, Campino S, Richardson A, Jallow M, Sisay-Joof F, Pinder M, Griffiths MJ, Peshu N, Williams TN, Marsh K, Molyneux ME, Taylor TE, Koram KA, Oduro AR, Rogers WO, Rockett KA, Haldar K, Kwiatkowski DP. Association of the GNAS locus with severe malaria. Hum Genet. 2008 Dec; 124(5): 499-506. PMCID: PMC2661463.
2. Bhattacharjee S, van Ooij C, Balu B, Adams JH, Haldar K. Maurer's clefts of plasmodium falciparum are secretory organelles that concentrate virulence protein reporters for delivery to the host erythrocyte. Blood. 2008 Feb 15; 111(4): 2418-2426. PMCID: PMC2234068.
3. Haldar K. Targeting the host to control an infection disorder. Arch Intern Med. 2008 Oct 27; 168(19): 2067-2068.
4. Haldar K, McFadden G. PLoS pathogens at three years. PLoS Pathog. 2008 Sep 26; 4(9): e1000167. PMCID: PMC2533063.
5. Haldar K, McFadden G, Young JA. Change in the editorial leadership of PLoS pathogens. PLoS Pathog. 2008 Jan; 4(1): e15. PMCID: PMC2323282.
6. Jackson LK, Nawabi P, Hentea C, Roark EA, Haldar K. The salmonella virulence protein SifA is a G protein antagonist. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37): 14141-14146. PMCID: PMC2544592.
7. MacKenzie JJ, Gomez ND, Bhattacharjee S, Mann S, Haldar K. A plasmodium falciparum host-targeting motif functions in export during blood stage infection of the rodent malarial parasite plasmodium berghei. PLoS ONE. 2008 Jun 11; 3(6): e2405. PMCID: PMC2396462.
8. Nawabi P, Catron DM, Haldar K. Esterification of cholesterol by a type III secretion effector during intracellular salmonella infection. Mol Microbiol. 2008 Apr; 68(1): 173-185.
9. Pollard AM, Onatolu KN, Hiller L, Haldar K, Knoll LJ. Highly polymorphic family of glycosylphosphatidylinositol-anchored surface antigens with evidence of developmental regulation in toxoplasma gondii. Infect Immun. 2008 Jan; 76(1): 103-110. PMCID: PMC2223667.
10. Roark EA, Haldar K. Effects of lysosomal membrane protein depletion on the salmonella-containing vacuole. PLoS ONE. 2008; 3(10): e3538. PMCID: PMC2568857.
11. Tamez PA, Bhattacharjee S, van Ooij C, Hiller NL, Llinas M, Balu B, Adams JH, Haldar K. An erythrocyte vesicle protein exported by the malaria parasite promotes tubovesicular lipid import from the host cell surface. PLoS Pathog. 2008 Aug 8; 4(8): e1000118. PMCID: PMC2483944.
12. van Ooij C, Tamez P, Bhattacharjee S, Hiller NL, Harrison T, Liolios K, Kooij T, Ramesar J, Balu B, Adams J, Waters AP, Janse CJ, Haldar K. The malaria secretome: From algorithms to essential function in blood stage infection. PLoS Pathog. 2008 Jun 13; 4(6): e1000084. PMCID: PMC2408878.
13. Guo D, Sarkar J, Suino-Powell K, Xu Y, Matsumoto K, Jia Y, Yu S, Khare S, Haldar K, Rao MS, Foreman JE, Monga SP, Peters JM, Xu HE, Reddy JK. Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver. J Biol Chem. 2007 Dec 14; 282(50): 36766-36776.
14. Haldar K, Mohandas N. Erythrocyte remodeling by malaria parasites. Curr Opin Hematol. 2007 May; 14(3): 203-209.
15. Haldar K, Murphy SC, Milner DA, Taylor TE. Malaria: Mechanisms of erythrocytic infection and pathological correlates of severe disease. Annu Rev Pathol. 2007; 2: 217-249.
16. Lopez-Estrano C, Gopalakrishnan AM, Semblat JP, Fergus MR, Mazier D, Haldar K. An enhancer-like region regulates hrp3 promoter stage-specific gene expression in the human malaria parasite plasmodium falciparum. Biochim Biophys Acta. 2007 Jul-Aug; 1769(7-8): 506-513. PMCID: PMC2267920.
17. Lopez-Estrano C, Semblat JP, Gopalakrishnan AM, Turner L, Mazier D, Haldar K. Plasmodium falciparum: Hrp3 promoter region is associated with stage-specificity and episomal recombination. Exp Parasitol. 2007 Jul; 116(3): 327-333. PMCID: PMC2267921.
18. Murphy SC, Fernandez-Pol S, Chung PH, Prasanna Murthy SN, Milne SB, Salomao M, Brown HA, Lomasney JW, Mohandas N, Haldar K. Cytoplasmic remodeling of erythrocyte raft lipids during infection by the human malaria parasite plasmodium falciparum. Blood. 2007 Sep 15; 110(6): 2132-2139. PMCID: PMC1976375.
19. Pei X, Guo X, Coppel R, Bhattacharjee S, Haldar K, Gratzer W, Mohandas N, An X. The ring-infected erythrocyte surface antigen (RESA) of plasmodium falciparum stabilizes spectrin tetramers and suppresses further invasion. Blood. 2007 Aug 1; 110(3): 1036-1042. PMCID: PMC1924765.
20. van Ooij C, Haldar K. Protein export from plasmodium parasites. Cell Microbiol. 2007 Mar; 9(3): 573-582.
21. Young J, Haldar K. The impact of PLoS pathogens. PLoS Pathog. 2007 Sep 7; 3(9): 1189-1190. PMCID: PMC2001159.
22. Bhattacharjee S, Hiller NL, Liolios K, Win J, Kanneganti TD, Young C, Kamoun S, Haldar K. The malarial host-targeting signal is conserved in the irish potato famine pathogen. PLoS Pathog. 2006 May; 2(5): e50. PMCID: PMC1464399.
23. Chaudhari A, Fialho AM, Ratner D, Gupta P, Hong CS, Kahali S, Yamada T, Haldar K, Murphy S, Cho W, Chauhan VS, Das Gupta TK, Chakrabarty AM. Azurin, plasmodium falciparum malaria and HIV/AIDS: Inhibition of parasitic and viral growth by azurin. Cell Cycle. 2006 Aug; 5(15): 1642-1648.
24. Haldar K, Kamoun S, Hiller NL, Bhattacharje S, van Ooij C. Common infection strategies of pathogenic eukaryotes. Nat Rev Microbiol. 2006 Dec; 4(12): 922-931.
25. Murphy SC, Harrison T, Hamm HE, Lomasney JW, Mohandas N, Haldar K. Erythrocyte G protein as a novel target for malarial chemotherapy. PLoS Med. 2006 Dec; 3(12): e528. PMCID: PMC1716186.
26. Murphy SC, Hiller NL, Harrison T, Lomasney JW, Mohandas N, Haldar K. Lipid rafts and malaria parasite infection of erythrocytes. Mol Membr Biol. 2006 Jan-Feb; 23(1): 81-88.
27. Haldar K, Hiller NL, van Ooij C, Bhattacharjee S. Plasmodium parasite proteins and the infected erythrocyte. Trends Parasitol. 2005 Sep; 21(9): 402-403.
28. Catron DM, Lange Y, Borensztajn J, Sylvester MD, Jones BD, Haldar K. Salmonella enterica serovar typhimurium requires nonsterol precursors of the cholesterol biosynthetic pathway for intracellular proliferation. Infect Immun. 2004 Feb; 72(2): 1036-1042. PMCID: PMC321618.
29. Hiller NL, Bhattacharjee S, van Ooij C, Liolios K, Harrison T, Lopez-Estrano C, Haldar K. A host-targeting signal in virulence proteins reveals a secretome in malarial infection. Science. 2004 Dec 10; 306(5703): 1934-1937.
30. Murphy SC, Samuel BU, Harrison T, Speicher KD, Speicher DW, Reid ME, Prohaska R, Low PS, Tanner MJ, Mohandas N, Haldar K. Erythrocyte detergent-resistant membrane proteins: Their characterization and selective uptake during malarial infection. Blood. 2004 Mar 1; 103(5): 1920-1928.
31. Braun PD, Barglow KT, Lin YM, Akompong T, Briesewitz R, Ray GT, Haldar K, Wandless TJ. A bifunctional molecule that displays context-dependent cellular activity. J Am Chem Soc. 2003 Jun 25; 125(25): 7575-7580.
32. Harrison T, Samuel BU, Akompong T, Hamm H, Mohandas N, Lomasney JW, Haldar K. Erythrocyte G protein-coupled receptor signaling in malarial infection. Science. 2003 Sep 19; 301(5640): 1734-1736.
33. Hiller NL, Akompong T, Morrow JS, Holder AA, Haldar K. Identification of a stomatin orthologue in vacuoles induced in human erythrocytes by malaria parasites. A role for microbial raft proteins in apicomplexan vacuole biogenesis. J Biol Chem. 2003 Nov 28; 278(48): 48413-48421.
34. Lopez-Estrano C, Bhattacharjee S, Harrison T, Haldar K. Cooperative domains define a unique host cell-targeting signal in plasmodium falciparum-infected erythrocytes. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21): 12402-12407. PMCID: PMC218770.
35. Nawabi P, Lykidis A, Ji D, Haldar K. Neutral-lipid analysis reveals elevation of acylglycerols and lack of cholesterol esters in plasmodium falciparum-infected erythrocytes. Eukaryot Cell. 2003 Oct; 2(5): 1128-1131. PMCID: PMC219371.
36. Akompong T, Kadekoppala M, Harrison T, Oksman A, Goldberg DE, Fujioka H, Samuel BU, Sullivan D, Haldar K. Trans expression of a plasmodium falciparum histidine-rich protein II (HRPII) reveals sorting of soluble proteins in the periphery of the host erythrocyte and disrupts transport to the malarial food vacuole. J Biol Chem. 2002 Aug 9; 277(32): 28923-28933.
37. Catron DM, Sylvester MD, Lange Y, Kadekoppala M, Jones BD, Monack DM, Falkow S, Haldar K. The salmonella-containing vacuole is a major site of intracellular cholesterol accumulation and recruits the GPI-anchored protein CD55. Cell Microbiol. 2002 Jun; 4(6): 315-328.
38. Cheresh P, Harrison T, Fujioka H, Haldar K. Targeting the malarial plastid via the parasitophorous vacuole. J Biol Chem. 2002 May 3; 277(18): 16265-16277.
39. Haldar K, Mohandas N, Samuel BU, Harrison T, Hiller NL, Akompong T, Cheresh P. Protein and lipid trafficking induced in erythrocytes infected by malaria parasites. Cell Microbiol. 2002 Jul; 4(7): 383-395.
40. Haldar K, Samuel BU, Mohandas N, Harrison T, Hiller NL. Transport mechanisms in plasmodium-infected erythrocytes: Lipid rafts and a tubovesicular network. Int J Parasitol. 2001 Oct; 31(12): 1393-1401.
41. Haldar K, Samuel BU, Mohandas N, Harrison T, Hiller NL. Erythrocytic vacuolar rafts induced by malaria parasites. Curr Opin Hematol. 2001 Mar; 8(2): 92-97.
42. Kadekoppala M, Cheresh P, Catron D, Ji DD, Deitsch K, Wellems TE, Seifert HS, Haldar K. Rapid recombination among transfected plasmids, chimeric episome formation and trans gene expression in plasmodium falciparum. Mol Biochem Parasitol. 2001 Feb; 112(2): 211-218.
43. Lauer SA, Chatterjee S, Haldar K. Uptake and hydrolysis of sphingomyelin analogues in plasmodium falciparum-infected red cells. Mol Biochem Parasitol. 2001 Jul; 115(2): 275-281.
44. Samuel BU, Mohandas N, Harrison T, McManus H, Rosse W, Reid M, Haldar K. The role of cholesterol and glycosylphosphatidylinositol-anchored proteins of erythrocyte rafts in regulating raft protein content and malarial infection. J Biol Chem. 2001 Aug 3; 276(31): 29319-29329.
45. Akompong T, Eksi S, Williamson K, Haldar K. Gametocytocidal activity and synergistic interactions of riboflavin with standard antimalarial drugs against growth of plasmodium falciparum in vitro. Antimicrob Agents Chemother. 2000 Nov; 44(11): 3107-3111. PMCID: PMC101611.
46. Akompong T, Ghori N, Haldar K. In vitro activity of riboflavin against the human malaria parasite plasmodium falciparum. Antimicrob Agents Chemother. 2000 Jan; 44(1): 88-96. PMCID: PMC89633.
47. Kadekoppala M, Kline K, Akompong T, Haldar K. Stable expression of a new chimeric fluorescent reporter in the human malaria parasite plasmodium falciparum. Infect Immun. 2000 Apr; 68(4): 2328-2332. PMCID: PMC97421.
48. Lauer S, VanWye J, Harrison T, McManus H, Samuel BU, Hiller NL, Mohandas N, Haldar K. Vacuolar uptake of host components, and a role for cholesterol and sphingomyelin in malarial infection. EMBO J. 2000 Jul 17; 19(14): 3556-3564. PMCID: PMC313993.
49. Akompong T, VanWye J, Ghori N, Haldar K. Artemisinin and its derivatives are transported by a vacuolar-network of plasmodium falciparum and their anti-malarial activities are additive with toxic sphingolipid analogues that block the network. Mol Biochem Parasitol. 1999 Jun 25; 101(1-2): 71-79.
50. Ming M, VanWye J, Janse CJ, Waters AP, Haldar K. Gene organization of rab6, a marker for the novel golgi of plasmodium. Mol Biochem Parasitol. 1999 May 25; 100(2): 217-222.
51. Sibley D, Haldar K. Molecular parasitology goes cellular. Cell Microbiol. 1999 Nov; 1(3): 259-262.
52. Bozdech Z, VanWye J, Haldar K, Schurr E. The human malaria parasite plasmodium falciparum exports the ATP-binding cassette protein PFGCN20 to membrane structures in the host red blood cell. Mol Biochem Parasitol. 1998 Nov 30; 97(1-2): 81-95.
53. Gnarpe J, Gnarpe H, Nissen K, Haldar K, Naas J. Chlamydia pneumoniae infection associated with multi-organ failure and fatal outcome in a previously healthy patient. Scand J Infect Dis. 1998; 30(5): 523-524.
54. Haldar K. Intracellular trafficking in plasmodium-infected erythrocytes. Curr Opin Microbiol. 1998 Aug; 1(4): 466-471.
55. Lauer SA, Rathod PK, Ghori N, Haldar K. A membrane network for nutrient import in red cells infected with the malaria parasite. Science. 1997 May 16; 276(5315): 1122-1125.
56. Shima DT, Haldar K, Pepperkok R, Watson R, Warren G. Partitioning of the golgi apparatus during mitosis in living HeLa cells. J Cell Biol. 1997 Jun 16; 137(6): 1211-1228. PMCID: PMC2132532.
57. VanWye JD, Haldar K. Expression of green fluorescent protein in plasmodium falciparum. Mol Biochem Parasitol. 1997 Aug; 87(2): 225-229.
58. Haldar K. Sphingolipid synthesis and membrane formation by plasmodium. Trends Cell Biol. 1996 Oct; 6(10): 398-405.
59. Van Wye J, Ghori N, Webster P, Mitschler RR, Elmendorf HG, Haldar K. Identification and localization of rab6, separation of rab6 from ERD2 and implications for an 'unstacked' golgi, in plasmodium falciparum. Mol Biochem Parasitol. 1996 Dec 2; 83(1): 107-120.
60. Lauer SA, Ghori N, Haldar K. Sphingolipid synthesis as a target for chemotherapy against malaria parasites. Proc Natl Acad Sci U S A. 1995 Sep 26; 92(20): 9181-9185. PMCID: PMC40948.
61. Li W, Keller GA, Haldar K. Recognition of a 170 kD protein in mammalian golgi complexes by an antibody against malarial intraerythrocytic lamellae. Tissue Cell. 1995 Aug; 27(4): 355-367.
62. Behari R, Haldar K. Plasmodium falciparum: Protein localization along a novel, lipid-rich tubovesicular membrane network in infected erythrocytes. Exp Parasitol. 1994 Nov; 79(3): 250-259.
63. Das A, Elmendorf HG, Li WI, Haldar K. Biosynthesis, export and processing of a 45 kDa protein detected in membrane clefts of erythrocytes infected with plasmodium falciparum. Biochem J. 1994 Sep 1; 302 ( Pt 2)(Pt 2): 487-496. PMCID: PMC1137254.
64. Elmendorf HG, Haldar K. Plasmodium falciparum exports the golgi marker sphingomyelin synthase into a tubovesicular network in the cytoplasm of mature erythrocytes. J Cell Biol. 1994 Feb; 124(4): 449-462. PMCID: PMC2119907.
65. Haldar K. Ducts, channels and transporters in plasmodium-infected erythrocytes. Parasitol Today. 1994 Oct; 10(10): 393-395.
66. Haldar K, Elmendorf HG, Das A, Li WL, Ferguson DJ, Elford BC. In vitro secretory assays with erythrocyte-free malaria parasites. Methods Cell Biol. 1994; 45: 221-246.
67. Elmendorf HG, Haldar K. Identification and localization of ERD2 in the malaria parasite plasmodium falciparum: Separation from sites of sphingomyelin synthesis and implications for organization of the golgi. EMBO J. 1993 Dec; 12(12): 4763-4773. PMCID: PMC413923.
68. Elmendorf HG, Haldar K. Secretory transport in plasmodium. Parasitol Today. 1993 Mar; 9(3): 98-102.
69. Haldar K, Holder AA. Export of parasite proteins to the erythrocyte in plasmodium falciparum-infected cells. Semin Cell Biol. 1993 Oct; 4(5): 345-353.
70. Crary JL, Haldar K. Brefeldin A inhibits protein secretion and parasite maturation in the ring stage of plasmodium falciparum. Mol Biochem Parasitol. 1992 Jul; 53(1-2): 185-192.
71. Dieckmann-Schuppert A, Bender S, Holder AA, Haldar K, Schwarz RT. Labeling and initial characterization of polar lipids in cultures of plasmodium falciparum. Parasitol Res. 1992; 78(5): 416-422.
72. Elmendorf HG, Bangs JD, Haldar K. Synthesis and secretion of proteins by released malarial parasites. Mol Biochem Parasitol. 1992 Jun; 52(2): 215-230.
73. Haldar K. Lipid transport in plasmodium. Infect Agents Dis. 1992 Oct; 1(5): 254-262.
74. Haldar K, Uyetake L. The movement of fluorescent endocytic tracers in plasmodium falciparum infected erythrocytes. Mol Biochem Parasitol. 1992 Jan; 50(1): 161-177.
75. Sanchez-Lopez R, Haldar K. A transferrin-independent iron uptake activity in plasmodium falciparum-infected and uninfected erythrocytes. Mol Biochem Parasitol. 1992 Oct; 55(1-2): 9-20.
76. Haldar K, Uyetake L, Ghori N, Elmendorf HG, Li WL. The accumulation and metabolism of a fluorescent ceramide derivative in plasmodium falciparum-infected erythrocytes. Mol Biochem Parasitol. 1991 Nov; 49(1): 143-156.
77. Li WL, Das A, Song JY, Crary JL, Haldar K. Stage-specific expression of plasmodial proteins containing an antigenic marker of the intraerythrocytic cisternae. Mol Biochem Parasitol. 1991 Nov; 49(1): 157-168.
78. Haldar K, de Amorim AF, Cross GA. Transport of fluorescent phospholipid analogues from the erythrocyte membrane to the parasite in plasmodium falciparum-infected cells. J Cell Biol. 1989 Jun; 108(6): 2183-2192. PMCID: PMC2115588.
79. Haldar K. Oscillatory flow of blood in a stenosed artery. Bull Math Biol. 1987; 49(3): 279-287.
80. Haldar K, Henderson CL, Cross GA. Identification of the parasite transferrin receptor of plasmodium falciparum-infected erythrocytes and its acylation via 1,2-diacyl-sn-glycerol. Proc Natl Acad Sci U S A. 1986 Nov; 83(22): 8565-8569. PMCID: PMC386971.
81. Ferguson MA, Haldar K, Cross GA. Trypanosoma brucei variant surface glycoprotein has a sn-1,2-dimyristyl glycerol membrane anchor at its COOH terminus. J Biol Chem. 1985 Apr 25; 260(8): 4963-4968.
82. Haldar K. Effects of the shape of stenosis on the resistance to blood flow through an artery. Bull Math Biol. 1985; 47(4): 545-550.
83. Haldar K, Ferguson MA, Cross GA. Acylation of a plasmodium falciparum merozoite surface antigen via sn-1,2-diacyl glycerol. J Biol Chem. 1985 Apr 25; 260(8): 4969-4974.
84. Haldar K, Olsiewski PJ, Walsh C, Kaczorowski GJ, Bhaduri A, Kaback HR. Simultaneous reconstitution of escherichia coli membrane vesicles with D-lactate and D-amino acid dehydrogenases. Biochemistry. 1982 Sep 14; 21(19): 4590-4596.
