Bayer Professor of Engineering
Director,Center for Micro-fluidics and Medical Diagnostics
University of Notre Dame
Department of Chemical and Biomolecular Engineering
University of Notre Dame
Notre Dame, IN
46556
Phone:
574 631 5697
Fax: 574 631 8366
Editor: Biomicrofluidics, an American Institute of Physics journal <bmf.aip.org>
Feature Article about CMMD in Bioscience Technology (PDF)<news>
Books: "Complex Wave Dynamics on Thin Films",H-C Chang and E A Demehkin, Elsevier (2002) <link>
"Electrokinetically Driven Microfluidics and Nanofluidics", H-C Chang and L Yeo, Cambridge Press(2009)<cover>
Recent Representative Papers
(See Publications for Complete List)
Review Articles
Yeo, L. and Chang, H.-C., "Static and Spontaneous Electrowetting", Modern Phys Lett. B ,19 ,549 (2005). (PDF)
Chang, H.-C., " Electrokinetics: A Viable Micro-fluidic Platform for Miniature Diagnostic Kits", Canadian J of Chemical Engineering, 84, 1(2006). (PDF)Chang, H.-C., "Nanobead Electrokinetics: The Enabling Microfluidic Platform for Rapid Multi-Target Detection" AIChE J., 53, 2486(2007) (pdf)
Sengupta, S., Gordon, J. E. and Chang, H.-C., "Microfluidic Diagnostic Systems for the Rapid Detection and Quantification of Pathogens", Chap 9 of "Microfluidics for Biological Applications",Editors: W-C Tien and E. Finehout, Springer (2008) (pdf)
Chang, H.-C., " Rapid and Portable Genetic Identification Kits for World Health Care Applications", Feature Article, Chinese American Chemical Society Communications, Summer Issue (2008). (pdf)
Chang, H.-C. and Yossifon, G., "Understanding Electrokineitcs at the Nanoscale--a Perspective", Biomicrofluidics, 3, 012001 (2009) (pdf)
Electrokinetics: Fundamentals
Ben, Y. and Chang, H.-C., "Nonlinear Smoluchowski Slip Velocity and Vortex Generation", J. Fluid Mech., 461, 229(2002).(PDF)
Thamida, S. and Chang, H.-C., "Nonlinear Electrokinetic Ejection and Entrainment due to Polarization at Nearly Insulated Wedges",Phys of Fluids, 14, 4315(2002).(PDF)
Takhistov, P., Indeikina, A. and Chang, H.-C., "Electrokinetic Displacement of Air Bubbles in Microchannels", Physics of Fluids, 14, 1(2002).(PDF)
Takhistov, P., Duginova, K. and Chang, H.-C., "Electrokinetic Mixing Vortices due to Electrolyte Depletion at Microchannel Junctions", J. of Colloid and Interfacial Science , 263 ,133-143 (2003). (PDF)
Ben, Y., Demekhin, E. A. and Chang, H.-C., "Superfast Nonlinear Electrokinetics and Electrophoresis", J of Collid and Interface Sci ., 276 , 483-497 (2004).
Yeo, L. and Chang, H.-C.,"Electro-Wetting Films on Parallel Line Electrodes", Phys Rev E,73,011605(2006) (PDF)
Hou, D. and Chang, H.-C., "Electrokinetic particle aggregation patterns in microvorticesdue to particle-field interaction", Phys. of Fluids , 18 , 071702 (2006). (PDF)
Zhou, R., Chang, H.-C., Protasenko, V., Kuno, M., Singh, A. K. and Jena, D., ""CdSe Nanowires with Illumination Enhanced Conducitivity: Induced Dipoles, DielectrophoreticAssembly and Field-Sensitive Assembly", J App Phys , 101 , 073704(2007). (PDF)
Basuray, S. and Chang, H.-C., "Induced Dipoles and Dielectrophoresis of Nano-Colloids in Electrolytes", Phys Rev E., 75, 060501-060504(2007). (PDF)
Maheshwari, S., Zhang, L., Y. Zhu and Chang, H.-C., " Coupling between Precipitation an Contact-line Dynamics: Multi-ring Stains and Stick-Slip Motion", Phys Rev Lett , 100 , 044503 (2008). (PDF)
Hou, D. and Chang, H.-C., "AC Field-Enhanced Protein Crystallization", Applied Phys Lett, 92, 223902 (2008) (PDF)
Yossifon, G. and Chang, H.-C., "Selection of Nonequilibrium Overlimiting Currents: Universal Depletion Layer Formation Dynamics and Vortex Instability", Phys. Rev. Lett,101, 254501(2008). (PDF)
Yossifon, G., Mushenheim, P., Chang, Y-C. and Chang, H.-C.,"Nonlinear Current-Voltage Characteristics of Nanochannels" Phys Rev E, 79, 046305 (2009). (PDF)
F. Plouraboue and Chang, H.-C., "Symmetry Breaking and Electrostatic Attraction Between Two Identical Surfaces", Phys. Rev. E, 79, 041404(2009). (PDF)
Yossifon, G., Chang, Y.-C. and Chang, H.-C., "Rectification, Gating Voltage and Interchannel Communication due to Asymmetric Entrance Space Charge Polarization", Phys Rev Lett., 103, 154502(2009). (PDF)
AC and DC Electrosprays
Yeo, L., Lastochkin, D., Wang, S.-C. and Chang, H.-C., "A New ac Electrospray Mechanism by Maxwell-Wagner Polarization and Capillary Resonance", Phys Rev Lett , 92,133902-133904 (2004). (PDF)
Chen. Z.. Wang, P. and Chang, H.-C., "An Electro-osmotic Micropump based on Monolithic Silica for Micro-flow Analyses and Electrosprays", Anal. Bioanal. Chem ., 382 , 817(2005). (PDF)<news>
Yeo, L., Gagnon, Z. and Chang, H.-C., "AC Electrospray Biomaterial Synthesis", Biomaterials , 26 , 6122( 2005). (PDF)
Wang, P., Chen, Z. and Chang, H.-C., "An integrated micropump and electrospray emitter system based on porous silica monoliths", Electrophoresis , 27 , 3964 (2006). (PDF)<news>
Yeo, L. and Chang, H.-C., "Static and Spontaneous Electrowetting", Modern Phys Lett. B ,19 ,549 (2005). (PDF)
Wang, P., Maheshwari, S. and Chang, H-C, "Polyhedra formation and transient cone ejection of a resonant microdrop forced by an ac electric field", Phys Rev Lett, 96, 254502 (2006)(PDF)<news>
Maheshwari, S. and Chang, H.-C., " Anomalous conical menisci under an ac field-departure from the dc Taylor cone", App Phys Lett, 89, 234103(2006). (PDF)
Maheshwari, S. and Chang, H.-C., "Effects of bulk charge and momentum relaxation times on ac electrospraying". J. App. Phys., 102,034902(2007). (PDF)
Chen, Z., Bogess, B. and Chang, H.-C., "Open-tubular Capillary Electrochromatography Mass Spectrometry with Sheathless Nanoflow Electrospray Ionization for the Analysis ofAmino Acids and Peptides", J of Mass Spectrometry , 42 , 244-253 (2007). (PDF) <news>
Chetwani, N., Maheshwari, S. and Chang, H.-C."Universal cone angle of ac electrosprays due to net charge entrainment", Phys Rev Lett, 101, 204501(2008). (PDF)
Maheshwari, S. and Chang, H.-C."Assembly of multi-stranded nanofiber threads through ac electrospinning", Adv Mater., 21,349-354(2009). (PDF)
Cheng, X. and Chang, H.-C. "Universal nanocolloid deposition patterns: can you see the harmonics of a Taylor cone ?", New J of Physics, 11, 075023(2009) (PDF)
Molecular Manipulation and Detection
Kreft, J., Chen, Y.-L. and Chang, H.-C., "Conformation and Trapping Rate of DNA at aConvergent Stagnant Flow", Phys Rev E., 77, 030801(R) (2008). (PDF)
Gagnon, Z., Senapati, S., Gordon, J. and Chang, H.-C., "Dielectrophoretic Detection and Quantification of Hybridized DNA Molecules on Nano-Genetic Beads", Electrophoresis, 29, 4808 (2008). (fast track and feature cover) (pdf)
Wang, S.-C., Wei, H.-H., Chen, H.-P., Tsai, M.-H., Yu, C.-C, and Chang, H.-C., "Dynamic Superconcentration at Critical Point Double-layer Gates of Conducting Nanoporous Granules due to Asymmetric Tangential Fluxes" Biomicrofluidics , 2 , 014012 (2008). (PDF)
S. Senapati, A. R. Mahon, J. Gordon, C. Nowak, S. Sengupta, T. H. W. Powell, J. Feder, D. M. Lodge and Chang, H.-C., "Rapid on-chip Genetic Detection Microfluidic Platform for Real World Applications", Biomicrofluidics, 3, 022407(2009).(pdf)
Basuray,S., Senapati,S., Aijian, A., Mahon, A.R. and Chang, H.-C., "Shear and AC Field Enhanced Carbon Nanotube Impedance Assay for Rapid, Sensitive and Mismatch-Discriminating DNA Hybridization", ACS Nano, 3, 1823 (2009).(pdf)
Micro-Devices and Pathogen/Cell Diagnostics
Wang, S. C,, Lai, Y. W., Ben, Y. and Chang, H.-C., "Microfluidic Mixing by DC and AC Nonlinear Electrokinetic Vortices", Ind. Eng. Fund. Res., 43, 2902-2911(2004).(PDF)
Lastochkin, D., Zhou, R., Wang, P., Ben, Y. and Chang, H.-C., "Electrokinetic Micropump and Micromixer Design Based on AC Faradaic Polarization", J. of Applied Physics , 96 , 1730 (2004). (PDF)
Wu, J., Ben, Y., Battigelli, D. and Chang, H.-C., "Long-Range AC Electroosmotic Trapping and Detection of Bioparticles", Ind. Eng. Chem. Res ., 44 , 2815(2005). (PDF)
Wu, J., Ben, Y. and Chang, H.-C., “Particle detection by electrical impedance spectroscopy with asymmetric-polarization ac electroosmotic trapping”, Microlfuid. And Nanofluid., 1, 161-167(2005)
Gagnon, Z. and Chang, H.-C., "Aligning fast alternating current electroosmotic flow fields and characteristic frequencies with dielectrophoretic traps to achieve rapidbacteriadetection", Electrophoresis , 26 , 3725-3737(2005). (PDF)
Zhou, R. and Chang, H.-C.,"Capillary Penetration Failure of Blood Suspensions", J of Colloidand Interfacial Sci ., 287 ,647 (2005.) (PDF)
Chen, Z., Hsu, F.-C.,Battigelli, D. and Chang, H.-C., "Capture and release of viruses using amino functionalized silica particles", Anal. Chim. Acta, 569, 76-82(2006). (PDF)
Wang, P., Chen, Z. and Chang, H.-C., "A New Electro-osmotic Pump Housed in Silica Monolith", Sensors and Actuators, 113, 500(2006) (PDF).<news>
Yeo, L. Y., Hou, D., Maheshwari, S. and Chang, H.-C., "Electrohydrodynamic surface microvortices for mixing and particle trapping", Appl. Phys. Lett., 88 , 233512 (2006). (PDF)<news item> <news>
Zhou, R., Gordon, J., Palmer, "A. and Chang, H.-C.,"Role of Eruthrocyte Deformability During Capillary Wetting", Biotechnology and Bioengineering, 93, 201-211(2006). (PDF)
Sengupta, S, Battigelli, D. A. and Chang, H.-C., "A micro-scale multi-frequency reactance measurment technique to detect bacterial growth at low-bioparticle concentrations", Lab-on-a-Chip, 6,682(2006) (PDF)
Zhou, R., Wang, P. and Chang, H.-C., "Bacteria capture, concentration and detection by AC dielectrophoresis and self-assembly of dispersed single-wall carbon nanotubes",Electrophoresis,27, 1375(2006)(PDF) <news item>
Hou, D., Maheshwari, M. and Chang, H.-C., "Rapid Bioparticle Concentration and Detection by Combining a Discharge Driven Vortex with Surface Enhanced Raman Scattering", Biomicrofluidics, 1, 014016(2007). (PDF)
Cheng, I-F.,Chang, H.-C., Hou, D. and Chang, H.-C., "An Integrated Dielectrophoretic Chip for Continuous Bioparticle Filtering, Focusing, Trapping and Detecting", Biomicrofluidics, 1, 021503(2007).(link)
Gordon, J. E., Gagnon, Z. and Chang, H.-C., "Dielectrophoretic Discrimination of Bovine Red Blood Cell Starvation Age by Buffer Selection and Membrane Cross-linking", Biomicrofluidics , 1 , 044102 (2007). (PDF)
Gagnon, Z., Gordon, J., Sengupta, S. and Chang, H.-C., "Bovine Red Blood Cell Starvation Age Discriminatin through a Glutaraldehyde Amplified Dielectrophoretic Approach with Buffer Selection and Membrane Cross-Linking", Electrophoresis , 29 , 2272 (2008). (PDF)
Gagnon, Z. and Chang, H.-C., "Dielectrophoresis of Ionized Gas Microbubbles: Dipole Reversal due to Diffusive Double Layer Polarization", Applied Phys Lett, 93, 224101(2008). (pdf)
Gagnon, Z. and Chang, H.-C., "Electrothermal ac Electro-osmosis", Applied Phys Lett., 94, 024101(2009) (pdf)
Education
BS Chemical Engineering, Caltech 1976
PhD Chemical Engineering, Princeton 1980
Awards and Lectures
Wallace
Memorial Honor Award, Princeton University, 1978
Regent's Junior Faculty Award, University of California, Santa Barbara,
1980
Presidential Young Investigator Award, National Science Foundation, 1985
Sigma Xi Outstanding Research Award, University of Notre Dame, 1990
Francois N. Frenkiel Award, Division of Fluid Dynamics of American Physical
Society, 1991
Fellow of the American Physical Society, Elected 1997
Colburn
Lectureship, University of Delaware, 1988
Keynote Lecture Second Joint US/China Chemical Engineering Conference,
Beijing, 1997
Keynote Lecture 13th International Congress of Chemical and Process Engineering
CHISA'98, Prague, 1998
Stanley Corrsin Hydrodynamics Lecture, Johns Hopkins University, 2002
Keynote Lecture, ASME Mini and Micro Channel Conference, Rochester, 2004
Keynote Lecture, Annual Biomedical Engineering Symposium, Tainan,Taiwan, 2004
Invited Lecture, BioSensor Symposium, Indianapolis, 2005.
Invited Lecture, International NanoEngineering Symposium, Tao Yuan,Taiwan,2005.
Keynote
Lecture, Annual Meeting of the Korean Society of Analytical Science and
Technology, Mokpo, 2006.
Invited Speaker, Advances in Microfluidics and Nanofluidics, HKUST, 2009.
Keynote Speaker, 83rd ACS Colloid & Surface Science Symposium, Columbia University, New York,2009.
Keynote Lecture, ASME Mini and Micro Channel Conference, Pohang, 2009.
Keynote Lecture, 2nd ASME Micro and Nanoscale Heat/Mass Tranfer, Jiaotung University Shanghai, 2009.
Keynote Lecture, Asia-Pacific Lab-on-Chip Conference, Fudan University, Shanghai, 2009.
Plenary Speaker, Wave Phenomena IV, Banff, Canada, 2010.
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