John Cheriyan, PhD                                                                                                                                 Postdoctoral Fellow

University of Notre Dame

Education                                                                                        

MS, Indian Institute of Technology, 2002

PhD, Rajiv Gandhi Centre for Biotechnology, 2009

Address
W. M. Keck Center for Transgene Research
230 Raclin-Carmichael Hall
University of Notre Dame
Notre Dame, IN 46556

Contact
Phone: (574) 631-2316
Fax: (574) 631-4048
E-mail: John.Cheriyan.1@nd.edu

Research Interests

I am interested in studying the mechanisms of action of compounds like conantokins which act as antagonists against NMDA receptor channel conductance with the goal of utilizing them for therapeutic use against neuronal damage in stroke. We are carrying out structure-function studies of their specific interaction with the channel subunits as a first step.

Selected Recent Publications

Cheriyan J, Kumar P, Mayadevi M, Surolia A, Omkumar RV.  (2011)  Calcium/calmodulin dependent protein kinase II bound to NMDA receptor 2B subunit exhibits increased ATP affinity and attenuated dephosphorylation.   PLoS One.   6:e16495.

Raveendran R, Devi Suma Priya S, Mayadevi M, Steephan M, Santhoshkumar TR, Cheriyan J, Sanalkumar R, Pradeep KK, James J, Omkumar RV.  (2009)   Phosphorylation status of the NR2B subunit of NMDA receptor regulates its interaction with calcium/calmodulin-dependent protein kinase II.  J Neurochem. 110:92-105.

Pradeep KK, Cheriyan J, Suma Priya SD, Rajeevkumar R, Mayadevi M, Praseeda M, Omkumar RV.  (2009)  Regulation of Ca2+/calmodulin-dependent protein kinase II catalysis by N-methyl-D-aspartate receptor subunit 2B.  Biochem J.   419:123-132, 4 p following 132.